N-[4-[(4-氯苯基)甲氧基]-2-吡啶基]-2,6-二氟苯乙酰胺

• 常用名: N-[4-[(4-氯苯基)甲氧基]-2-吡啶基]-2,6-二氟苯乙酰胺
• 英文名: CPDA
• CAS号: 1415834-63-7
• 分子量: 388.79500
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₅ClF₂N₂O₂
• 熔点: N/A
• 闪点: N/A

用途

CPDA是一种新型有效的 SH2 domain-containing inositol phosphatase 2 (SHIP2) 抑制剂, 作用于3T3-L1脂肪细胞, 能够有效改善胰岛素抗性。

名称

• 中文名: CPDA
• 英文名: cpda

生物活性

• 描述: CPDA是一种新型有效的 SH2 domain-containing inositol phosphatase 2 (SHIP2) 抑制剂, 作用于3T3-L1脂肪细胞, 能够有效改善胰岛素抗性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2). Eur J Med Chem. 2013 Apr;62:649-660.

物理化学性质

• 分子式: C₂₀H₁₅ClF₂N₂O₂
• 分子量: 388.79500
• 精确质量: 388.07900
• PSA: 51.22000
• LogP: 4.84640
• InChIKey: GISJHCLTIVIGLX-UHFFFAOYSA-N
• SMILES: O=C(Cc1c(F)cccc1F)Nc1cc(OCc2ccc(Cl)cc2)ccn1
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Toxicity in db/db mouse assessed as epididymal white adipose tissue weight at 300 mg/... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2342655

实验名称：Toxicity in C57BL/6J mouse assessed as effect on glucose tolerance at 300 mg/kg, po b... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2342654

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Toxicity in C57BL/6J mouse assessed as serum insulin level at 300 mg/kg, po bid for 1... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2342659

实验名称：Toxicity in db/db mouse assessed as body weight at 300 mg/kg, po bid for 12 to 13 day... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2342658

实验名称：Toxicity in db/db mouse assessed as liver weight at 300 mg/kg, po bid for 12 to 13 da... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2342657

实验名称：Toxicity in db/db mouse assessed as food intake at 300 mg/kg, po bid for 12 to 13 day... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2342656

实验名称：Inhibition of SHIP2 in mouse 3T3L1 cells assessed as reduction of TNF-alpha induced d... 来源：ChEMBL 靶标：Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 External Id：CHEMBL2343087

实验名称：Inhibition of SHIP2 in TNF alpha-treated mouse 3T3L1 cells assessed as potentiation o... 来源：ChEMBL 靶标：Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 External Id：CHEMBL2343086

实验名称：Inhibition of SHIP2 in TNF alpha-treated Sprague-Dawley rat cortical neuron assessed ... 来源：ChEMBL 靶标：Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 External Id：CHEMBL2343085

共40条，当前第1页，共4页

1

2

3

4

英文别名

• N-[4-[(4-Chlorophenyl)methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetamide