JW 642

• 常用名: JW 642
• 英文名: JW 642
• CAS号: 1416133-89-5
• 分子量: 462.385
• 密度: 1.4±0.1 g/cm3
• 沸点: 432.9±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₀F₆N₂O₃
• 熔点: N/A
• 闪点: 215.6±28.7 °C

JW 642用途

JW 642是一高效MAGL抑制剂,对小鼠、大鼠和人源脑细胞膜上MAGL的IC50值分别为7.6nM、14nM和3.7nM。

JW 642名称

• 中文名: JW 642
• 英文名: 1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazin ecarboxylate

JW 642生物活性

• 描述: JW 642是一高效MAGL抑制剂,对小鼠、大鼠和人源脑细胞膜上MAGL的IC50值分别为7.6nM、14nM和3.7nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MAGL
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.

JW 642物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 432.9±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₀F₆N₂O₃
• 分子量: 462.385
• 闪点: 215.6±28.7 °C
• 精确质量: 462.137817
• PSA: 42.01000
• LogP: 6.43
• InChIKey: AVSCNEOUWSVZEY-UHFFFAOYSA-N
• SMILES: O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.511
• 储存条件: 2-8℃

JW 642靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrat... 来源：ChEMBL 靶标：Monoglyceride lipase External Id：CHEMBL3384490

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：In Vitro Competitive Activity-Based Protein Assay from US Patent US9133148: "Carbamat... 来源：BindingDB 靶标：N/A External Id：BindingDB_7190_1

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as subs... 来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1 External Id：CHEMBL3384493

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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JW 642英文别名

• 1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazinecarboxylate
• 1,1,1,3,3,3-hexafluoroisopropyl cyanoacetate
• 1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
• JW 642
• JW-642