法罗培南酯

• 常用名: 法罗培南酯
• 英文名: Faropenem medoxomil
• CAS号: 141702-36-5
• 分子量: 397.40000
• 密度: 1.55 g/cm3
• 沸点: 622.3ºC at 760 mmHg
• 分子式: C₁₇H₁₉NO₈S
• 熔点: N/A
• 闪点: N/A

法罗培南酯用途

Faropenem daloxate是口服的β-内酰胺类抗生素。

法罗培南酯名称

• 中文名: 法罗培南酯
• 英文名: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• 中文别名: (5R,6S)-6-[1(R)-羟基乙基]-2-[2(R)-四氢呋喃基]-2-培南-3-甲酸 5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基甲酯

法罗培南酯生物活性

• 描述: Faropenem daloxate是口服的β-内酰胺类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Faqi AS, Lanphear C, Gill S, Colagiovanni DB.Juvenile toxicity study of faropenem medoxomil in beagle puppies.Reprod Toxicol. 2010 Dec;30(4):619-24. Epub 2010 Aug 11.

  [2]. Hadley JA, Tillotson GS, Tosiello R, Echols RM.Faropenem medoxomil: a treatment option in acute bacterial rhinosinusitis.Expert Rev Anti Infect Ther. 2006 Dec;4(6):923-37.

  [3]. Siegert R, Berg O, Gehanno P, Leiberman A, Martinkenas JL, Nikolaidis P, Arvis P, Alefelder M, Reimnitz P.Comparison of the efficacy and safety of faropenem daloxate and cefuroxime axetil for the treatment of acute bacterial maxillary sinusitis in adults.

  [4]. Upchurch J, Rosemore M, Tosiello R, Kowalsky S, Echols R.Randomized double-blind study comparing 7- and 10-day regimens of faropenem medoxomil with a 10-day cefuroxime axetil regimen for treatment of acute bacterial sinusitis.Otolaryngol Head Neck Surg. 2

  [5]. Gettig, Jacob P.; Crank, Christopher W.; Philbrik, Alexander H. Faropenem medoxomil. Annals of Pharmacotherapy (2008), 42(1), 80-90.

法罗培南酯物理化学性质

• 密度: 1.55 g/cm3
• 沸点: 622.3ºC at 760 mmHg
• 分子式: C₁₇H₁₉NO₈S
• 分子量: 397.40000
• 精确质量: 397.08300
• PSA: 144.72000
• LogP: 0.82500
• InChIKey: JQBKWZPHJOEQAO-DVPVEWDBSA-N
• SMILES: Cc1oc(=O)oc1COC(=O)C1=C(C2CCCO2)SC2C(C(C)O)C(=O)N12
• 外观性状: 白色粉末
• 蒸汽压: 4.3E-18mmHg at 25°C
• 折射率: 1.642
• 储存条件: 2-8℃

法罗培南酯靶点实验

查看更多实验

实验名称：Antibacterial activity against Streptococcus pneumoniae clinical isolates 来源：ChEMBL 靶标：Streptococcus pneumoniae External Id：CHEMBL1266592

实验名称：f%TMIC in ip dosed Bacillus anthracis Ames infected BALB/c mouse model at ED99 admini... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1266591

实验名称：f%TMIC in ip dosed Bacillus anthracis Ames infected BALB/c mouse model at ED90 admini... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1266590

实验名称：f%TMIC in ip dosed Bacillus anthracis Ames infected BALB/c mouse model at ED50 admini... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1266589

实验名称：Antibacterial activity against Bacillus anthracis Ames infected in BALB/c mouse asses... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1266587

实验名称：Antibacterial activity against Bacillus anthracis Ames infected in BALB/c mouse asses... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1266586

实验名称：Antibacterial activity against Bacillus anthracis Ames infected in BALB/c mouse asses... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1266585

实验名称：f%TMIC in Bacillus anthracis Ames infected pharmacokinetic-pharmacodynamic model at 0... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1266600

实验名称：f%TMIC in Bacillus anthracis Ames infected pharmacokinetic-pharmacodynamic model at 0... 来源：ChEMBL 靶标：Bacillus anthracis External Id：CHEMBL1266599

实验名称：f%TMIC in Bacillus anthracis Ames infected human model at 600 mg/kg, BID 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1266598

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法罗培南酯英文别名

• Faropenem medoxomil (USAN)
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• Faropenem daloxate
• Orapem
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• Faropenem medoxomil
• A0026