HDAC4-IN-1

• 常用名: HDAC4-IN-1
• 英文名: HDAC4-IN-1
• CAS号: 1418293-39-6
• 分子量: 356.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₉F₃N₄O₂
• 熔点: N/A
• 闪点: N/A

HDAC4-IN-1用途

HDAC4-IN-1 (compound 1a) 是 IIa 类 HDACI 抑制剂 (IC50=0.077 μM)。HDAC4-IN-1 可以增强 caspase 诱导的细胞凋亡 (Apoptosis). HDAC4-IN-1 具有抗癌活性。HDAC4-IN-1 能够用于药物联合抗癌的研究。

HDAC4-IN-1名称

• 英文名: HDAC4-IN-1

HDAC4-IN-1生物活性

• 描述: HDAC4-IN-1 (compound 1a) 是 IIa 类 HDACI 抑制剂 (IC50=0.077 μM)。HDAC4-IN-1 可以增强 caspase 诱导的细胞凋亡 (Apoptosis). HDAC4-IN-1 具有抗癌活性。HDAC4-IN-1 能够用于药物联合抗癌的研究。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  HDAC2:6.13 μM (IC50)

  HDAC4:0.012 μM (IC50)

  HDAC6:5.79 μM (IC50)

  HDAC8:4.26 μM (IC50)

• 参考文献:

  [1]. Asfaha Y, et al. 5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib. Eur J Med Chem. 2023 Nov 10;263:115907.

HDAC4-IN-1物理化学性质

• 分子式: C₁₆H₁₉F₃N₄O₂
• 分子量: 356.34

HDAC4-IN-1靶点实验

查看更多实验

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537782

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537781

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537780

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537779

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537778

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537777

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537776

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537775

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537774

实验名称：Synergistic antiproliferative activity against human CAL-27 cells overexpressing HDAC... 来源：ChEMBL 靶标：CAL-27 External Id：CHEMBL5537773

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