(2Z)-3-[3-[3,5-双(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-1-(3,3-二氟-1-氮杂环丁基)-2-丙烯-1-酮

更新时间：2025-08-21 15:30:17

(2Z)-3-[3-[3,5-双(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-1-(3,3-二氟-1-氮杂环丁基)-2-丙烯-1-酮结构式	常用名	(2Z)-3-[3-[3,5-双(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-1-(3,3-二氟-1-氮杂环丁基)-2-丙烯-1-酮	英文名	KPT-276
	CAS号	1421919-75-6	分子量	426.264
	密度	1.6±0.1 g/cm3	沸点	477.2±55.0 °C at 760 mmHg
	分子式	C₁₆H₁₀F₈N₄O	熔点	N/A
	MSDS	N/A	闪点	242.4±31.5 °C

中文名	(2Z)-3-[3-[3,5-双(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-1-(3,3-二氟-1-氮杂环丁基)-2-丙烯-1-酮
英文名	(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
英文别名	更多

描述
相关类别	信号通路 >> 跨膜转运 >> CRM1 研究领域 >> 癌症
参考文献	[1]. Ranganathan P, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012 Aug 30;120(9):1765-73. [2]. Zhang K, et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol. 2013 Jan;41(1):67-78.e4. [3]. Schmidt J, et al. Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276. Leukemia. 2013 Dec;27(12):2357-65.

描述

相关类别

信号通路 >> 跨膜转运 >> CRM1

研究领域 >> 癌症

参考文献

[1]. Ranganathan P, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012 Aug 30;120(9):1765-73.

[2]. Zhang K, et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol. 2013 Jan;41(1):67-78.e4.

[3]. Schmidt J, et al. Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276. Leukemia. 2013 Dec;27(12):2357-65.

密度	1.6±0.1 g/cm3
沸点	477.2±55.0 °C at 760 mmHg
分子式	C₁₆H₁₀F₈N₄O
分子量	426.264
闪点	242.4±31.5 °C
精确质量	426.072693
PSA	51.02000
LogP	3.41
InChIKey	JCHAWRDHMUSLMM-UHFFFAOYSA-N
SMILES	O=C(C=Cn1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)N1CC(F)(F)C1
外观性状	粉末
蒸汽压	0.0±1.2 mmHg at 25°C
折射率	1.530
储存条件	-20℃

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

实验名称：MELAS cybrid survival enhancement under low glucose conditions
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：N/A
External Id：HMS1419

实验名称：Stabilization of p53 in human papillomavirus-positive cells
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：Cellular tumor antigen p53
External Id：HMS1485

共3条，当前第1页，共1页

kpt-276

s7251

(2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one