GSK2818713

• 常用名: GSK2818713
• 英文名: GSK2818713
• CAS号: 1422484-32-9
• 分子量: 848.99
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₆H₅₆N₈O₈
• 熔点: N/A
• 闪点: N/A

GSK2818713用途

GSK2818713是一种新型丙型肝炎NS5A复制复合物抑制剂。

GSK2818713名称

• 英文名: GSK2818713

GSK2818713生物活性

• 描述: GSK2818713是一种新型丙型肝炎NS5A复制复合物抑制剂。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> HCV蛋白酶
• 参考文献:

  [1]. Kazmierski WM, et al. GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage. J Med Chem. 2020 Apr 23;63(8):4155-4170.

GSK2818713物理化学性质

• 分子式: C₄₆H₅₆N₈O₈
• 分子量: 848.99
• InChIKey: PJGLLJHUBRGNEG-KDDSMZEWSA-N
• SMILES: COC(=O)NC(C(=O)N1C(c2ncc(-c3ccc4c(c3)=c3ccc(-c5cnc(C6CC7CCCC7N6C(=O)C(NC(=O)OC)C(C)OC)[nH]5)cc3=4)[nH]2)CC2CCCC21)C(C)OC

GSK2818713靶点实验

查看更多实验

实验名称：Inhibition of HCV NS5A infected in HuH-Lcu-Neo cells assessed as reduction in viral r... 来源：ChEMBL 靶标：Nonstructural protein 5A External Id：CHEMBL4359249

实验名称：Inhibition of HCV NS5A infected in HuH-Lcu-Neo cells assessed as reduction in viral r... 来源：ChEMBL 靶标：Nonstructural protein 5A External Id：CHEMBL4359248

实验名称：Inhibition of HCV NS5A infected in HuH-Lcu-Neo cells assessed as reduction in viral r... 来源：ChEMBL 靶标：Nonstructural protein 5A External Id：CHEMBL4359247

实验名称：Inhibition of HCV NS5A infected in HuH-Lcu-Neo cells assessed as reduction in viral r... 来源：ChEMBL 靶标：Nonstructural protein 5A External Id：CHEMBL4359246

实验名称：Inhibition of HCV genotype 3a con NS5A infected in HuH-Lcu-Neo cells assessed as fold... 来源：ChEMBL 靶标：Nonstructural protein 5A External Id：CHEMBL4359245

实验名称：Inhibition of HCV genotype 2a con NS5A infected in HuH-Lcu-Neo cells assessed as fold... 来源：ChEMBL 靶标：Nonstructural protein 5A External Id：CHEMBL4359244

实验名称：AUC (0 to infinity) in Beagle dog at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4359235

实验名称：AUC (0 to t) in Beagle dog at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4359234

实验名称：Half life in Beagle dog at 1 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4359233

实验名称：Volume of distribution at steady state in Beagle dog at 1 mg/kg, iv by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4359232

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