ML-243

• 常用名: ML-243
• 英文名: ML-243
• CAS号: 1426576-80-8
• 分子量: 260.355
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₄H₁₆N₂OS
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

ML-243用途

ML243是乳腺癌干细胞的选择性小分子抑制剂。ML243在乳腺癌样细胞系HMLE\u-shECad中的选择性抑制比对照细胞系HMLE\u-shGFP[1]高32倍。

ML-243名称

• 中文名: ML-243
• 英文名: (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)acrylamide

ML-243生物活性

• 描述: ML243是乳腺癌干细胞的选择性小分子抑制剂。ML243在乳腺癌样细胞系HMLE\u-shECad中的选择性抑制比对照细胞系HMLE\u-shGFP[1]高32倍。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  Breast CSCs[1]

• 参考文献:

  [1]. Carmody L, et al. Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3. 2011 Sep 28 [updated 2013 Mar 7].

ML-243物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₁₄H₁₆N₂OS
• 分子量: 260.355
• 精确质量: 260.098328
• PSA: 70.25000
• LogP: 2.65
• InChIKey: MTLJBAFNMHPGBV-BQYQJAHWSA-N
• SMILES: CCc1ccc(C=CC(=O)NC2=NCCS2)cc1
• 折射率: 1.608
• 储存条件: -20°C，密闭，干燥

ML-243安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport

ML-243靶点实验

查看更多实验

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify act... 来源：The Scripps Research Institute Molecular Screening Center 靶标：TTR [Homo sapiens] External Id：TTR_ACT_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Metabolic stability in human plasma after 5 hrs 来源：ChEMBL 靶标：Plasma External Id：CHEMBL2393885

实验名称：Chemical stability of the compound after 48 hrs in presence of GSH 来源：ChEMBL 靶标：N/A External Id：CHEMBL2393884

实验名称：Chemical stability in DMSO after 48 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL2393882

实验名称：Selectivity ratio of EC50 for human HMLE cells expressing shRNA and GFP to EC50 for h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2393889

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

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ML-243英文别名

• (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)acrylamide
• Streptomyces metabolite 2880 II
• 2880-II