JNJ-42253432

更新时间：2025-08-25 19:11:40

JNJ-42253432结构式	常用名	JNJ-42253432	英文名	JNJ-42253432
	CAS号	1428327-35-8	分子量	446.639
	密度	N/A	沸点	N/A
	分子式	C₂₈H₃₈N₄O	熔点	N/A
	MSDS	N/A	闪点	N/A

JNJ-42253432用途

一种有效的,选择性的CNS渗透性P2X7拮抗剂,大鼠和huamn P2X7通道的pKi分别为9.1和7.9；在10μM时不通过人P2X1,P2X2,P2X3,P2X2/P2X3和P2X4阻断钙通量；减弱ATP-和Bz-ATP诱导的来自具有相似效力的hP2X7-1321N1细胞的电流(pEC50=7.0),阻断Bz ATP在自由移动的大鼠脑中诱导的IL-1β的释放,也增加5-羟色胺水平；减弱安非他明诱导的体内活动过度。

英文名	JNJ-42253432

描述	一种有效的,选择性的CNS渗透性P2X7拮抗剂,大鼠和huamn P2X7通道的pKi分别为9.1和7.9；在10μM时不通过人P2X1,P2X2,P2X3,P2X2/P2X3和P2X4阻断钙通量；减弱ATP-和Bz-ATP诱导的来自具有相似效力的hP2X7-1321N1细胞的电流(pEC50=7.0),阻断Bz ATP在自由移动的大鼠脑中诱导的IL-1β的释放,也增加5-羟色胺水平；减弱安非他明诱导的体内活动过度。
参考文献	References 1. Lord B, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41. 2. Amhaoul H, et al. Neuropharmacology. 2016 Jun;105:175-185. View Related Products by Target P2X Receptor

描述

参考文献

References 1. Lord B, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41. 2. Amhaoul H, et al. Neuropharmacology. 2016 Jun;105:175-185. View Related Products by Target P2X Receptor

分子式	C₂₈H₃₈N₄O
分子量	446.639
InChIKey	DIKKTLPJDURHSW-UHFFFAOYSA-N
SMILES	CN1CCc2c(cccc2C(=O)NCC2(N3CCN(c4ccccc4)CC3)CCCCC2)C1

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