ML254

• 常用名: ML254
• 英文名: ML254
• CAS号: 1428630-86-7
• 分子量: 310.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₅FN₂O₂
• 熔点: N/A
• 闪点: N/A

ML254用途

ML254是一种有效的mGlu5增强剂,对大鼠mGlu5的EC50和pEC50分别为9.3 nM和8.03 nM。ML254可用于研究精神分裂症[1]。

ML254名称

• 英文名: ML 254

ML254生物活性

• 描述: ML254是一种有效的mGlu5增强剂,对大鼠mGlu5的EC50和pEC50分别为9.3 nM和8.03 nM。ML254可用于研究精神分裂症[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  rat mGluR5:9.3 nM (EC50)

  rat mGluR5:8.03 nM (pEC50)

• 参考文献:

  [1]. Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J Med Chem. 2013;56(20):7976-7996.

ML254物理化学性质

• 分子式: C₁₈H₁₅FN₂O₂
• 分子量: 310.32
• InChIKey: YMYCVXPMSMNWEP-UHFFFAOYSA-N
• SMILES: CC1(NC(=O)c2ccc(C#Cc3cccc(F)c3)cn2)COC1

ML254靶点实验

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