抗菌肽TP4 (Nile tilapia piscidin)

• 常用名: 抗菌肽TP4 (Nile tilapia piscidin)
• 英文名: TP4 (Nile tilapia piscidin)
• CAS号: 1429184-62-2
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

抗菌肽TP4 (Nile tilapia piscidin)用途

TP4 (Nile tilapia piscidin) 是一种具有口服活性的 piscidin 样抗菌肽。TP4 抑制多种革兰氏阳性和阴性菌株 (MIC: 0.03-10 μg/mL)。TP4 显示出溶血活性。TP4 增强免疫反应、抗氧化活性和肠道健康,以抵抗细菌感染。TP4 还具有抗肿瘤作用,并通过触发癌细胞线粒体功能障碍来诱导坏死 (necrosis)。

抗菌肽TP4 (Nile tilapia piscidin)名称

• 中文名: 抗菌肽TP4 (NILE TILAPIA PISCIDIN)
• 英文名: TP4 (Nile tilapia piscidin)

抗菌肽TP4 (Nile tilapia piscidin)生物活性

• 描述: TP4 (Nile tilapia piscidin) 是一种具有口服活性的 piscidin 样抗菌肽。TP4 抑制多种革兰氏阳性和阴性菌株 (MIC: 0.03-10 μg/mL)。TP4 显示出溶血活性。TP4 增强免疫反应、抗氧化活性和肠道健康,以抵抗细菌感染。TP4 还具有抗肿瘤作用,并通过触发癌细胞线粒体功能障碍来诱导坏死 (necrosis)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Peng KC, et al. Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. PLoS One. 2012;7(11):e50263.

  [2]. Su BC, et al. Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant p53 Glioblastoma Cells. Cancers (Basel). 2019 Feb 1;11(2):171.

  [3]. Eman Zahran, et al. Tilapia piscidin 4 (TP4) enhances immune response, antioxidant activity, intestinal health and protection against Streptococcus iniae infection in Nile tilapia. Aquaculture. Volume 513, 15 November 2019, 734451.

抗菌肽TP4 (Nile tilapia piscidin)物理化学性质

暂时没有任何物化性质资料

抗菌肽TP4 (Nile tilapia piscidin)靶点实验

查看更多实验

实验名称：Induction of cell membrane depolarization in Klebsiella pneumoniae BAA 2473 assessed ... 来源：ChEMBL 靶标：Cell membrane External Id：CHEMBL5506401

实验名称：Induction of outer cell membrane permeabilization in Klebsiella pneumoniae BAA 2473 a... 来源：ChEMBL 靶标：Cell membrane External Id：CHEMBL5506400

实验名称：Displacement of BODIPY-TR-cadaverine from Klebsiella pneumoniae BAA 2473 lipopolysacc... 来源：ChEMBL 靶标：Lipopolysaccharide (LPS) External Id：CHEMBL5506399

实验名称：Antibacterial activity against Klebsiella pneumoniae BAA 2473 assessed as bacterial e... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL5506396

实验名称：Hemolytic activity in human Red blood cells assessed as hemolysis at 3.13 uM incubate... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL5506394

实验名称：Induction of morphological changes in Klebsiella pneumoniae BAA 2473 assessed as memb... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL5506403

共6条，当前第1页，共1页

1