抗菌肽TP4 (Nile tilapia piscidin)

• 常用名: 抗菌肽TP4 (Nile tilapia piscidin)
• 英文名: TP4 (Nile tilapia piscidin)
• CAS号: 1429184-62-2
• 分子量: 2981.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃₅H₂₂₆N₅₀O₂₇
• 熔点: N/A
• 闪点: N/A

抗菌肽TP4 (Nile tilapia piscidin)用途

TP4 (Nile tilapia piscidin) 是一种具有口服活性的 piscidin 样抗菌肽。TP4 抑制多种革兰氏阳性和阴性菌株 (MIC: 0.03-10 μg/mL)。TP4 显示出溶血活性。TP4 增强免疫反应、抗氧化活性和肠道健康,以抵抗细菌感染。TP4 还具有抗肿瘤作用,并通过触发癌细胞线粒体功能障碍来诱导坏死 (necrosis)。

抗菌肽TP4 (Nile tilapia piscidin)名称

• 中文名: 抗菌肽TP4 (NILE TILAPIA PISCIDIN)
• 英文名: TP4 (Nile tilapia piscidin)

抗菌肽TP4 (Nile tilapia piscidin)生物活性

• 描述: TP4 (Nile tilapia piscidin) 是一种具有口服活性的 piscidin 样抗菌肽。TP4 抑制多种革兰氏阳性和阴性菌株 (MIC: 0.03-10 μg/mL)。TP4 显示出溶血活性。TP4 增强免疫反应、抗氧化活性和肠道健康,以抵抗细菌感染。TP4 还具有抗肿瘤作用,并通过触发癌细胞线粒体功能障碍来诱导坏死 (necrosis)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Peng KC, et al. Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. PLoS One. 2012;7(11):e50263.

  [2]. Su BC, et al. Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant p53 Glioblastoma Cells. Cancers (Basel). 2019 Feb 1;11(2):171.

  [3]. Eman Zahran, et al. Tilapia piscidin 4 (TP4) enhances immune response, antioxidant activity, intestinal health and protection against Streptococcus iniae infection in Nile tilapia. Aquaculture. Volume 513, 15 November 2019, 734451.

抗菌肽TP4 (Nile tilapia piscidin)物理化学性质

• 分子式: C₁₃₅H₂₂₆N₅₀O₂₇
• 分子量: 2981.6
• 精确质量: 2980.7882070
• InChIKey: HYAWOKZBJCYAJI-SJLLAERXSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC5=CC=CC=C5)N

抗菌肽TP4 (Nile tilapia piscidin)靶点实验

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