YYA-021

• 常用名: YYA-021
• 英文名: YYA-021
• CAS号: 144217-65-2
• 分子量: 317.42600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₇N₃O₂
• 熔点: N/A
• 闪点: N/A

YYA-021用途

YYA-021是一种小分子CD4模拟物, 抑制HIV进入, 具有高效抗HIV活性和低细胞毒性。

YYA-021名称

• 中文名: YYA-021
• 英文名: yya-021

YYA-021生物活性

• 描述: YYA-021是一种小分子CD4模拟物, 抑制HIV进入, 具有高效抗HIV活性和低细胞毒性。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Mizuguchi T, et al. A minimally cytotoxic CD4 mimic as an HIV entry inhibitor. Bioorg Med Chem Lett. 2016 Jan 15;26(2):397-400.

  [2]. Hashimoto C, et al. A CD4 mimic as an HIV entry inhibitor: pharmacokinetics. Bioorg Med Chem. 2013 Dec 15;21(24):7884-9.

YYA-021物理化学性质

• 分子式: C₁₈H₂₇N₃O₂
• 分子量: 317.42600
• 精确质量: 317.21000
• PSA: 70.23000
• LogP: 3.15160
• InChIKey: AYAGJQPDCPRMNG-UHFFFAOYSA-N
• SMILES: Cc1ccc(NC(=O)C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1
• 外观性状: 粉末
• 储存条件: -20℃

YYA-021靶点实验

查看更多实验

实验名称：Inhibition of CD4-induced monoclonal antibody 4C11 binding to HIV1 MNA infected in hu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1259502

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytotoxicity against human PM1 cells expressing CCR5 by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1259501

实验名称：Antiviral activity against HIV1 MNA infected in human PM1 cells expressing CCR5 asses... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1259500

实验名称：Inhibition of gp120 binding to CD4 in HIV1 JR-FL infected human PM1 cells assessed as... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1065280

实验名称：Initial plasma concentration in Jcl:Sprague-Dawley rat at 14 mg/kg, iv by HPLC analys... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3095911

实验名称：Volume of distribution in Jcl:Sprague-Dawley rat at 14 mg/kg, iv by HPLC analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3095912

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

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YYA-021英文别名

• N-(2,2,6,6-Tetramethyl-piperidin-4-yl)-N'-p-tolyl-oxalamide