VHL Ligand 3

• 常用名: VHL Ligand 3
• 英文名: VHL Ligand 3
• CAS号: 1448189-98-7
• 分子量: 530.679
• 密度: 1.2±0.1 g/cm3
• 沸点: 755.7±60.0 °C at 760 mmHg
• 分子式: C₂₇H₃₈N₄O₅S
• 熔点: N/A
• 闪点: 410.9±32.9 °C

VHL Ligand 3用途

PROTAC的VHL配体。

VHL Ligand 3名称

• 英文名: 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide

VHL Ligand 3生物活性

• 描述: PROTAC的VHL配体。
• 参考文献: References 1. Wurz RP, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01781. 2. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. View Related Products by Target E3 Ligase Ligand

VHL Ligand 3物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 755.7±60.0 °C at 760 mmHg
• 分子式: C₂₇H₃₈N₄O₅S
• 分子量: 530.679
• 闪点: 410.9±32.9 °C
• 精确质量: 530.256287
• LogP: 2.63
• InChIKey: PKNFPFFOAWITLF-RZUBCFFCSA-N
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)cc1
• 蒸汽压: 0.0±2.7 mmHg at 25°C
• 折射率: 1.572
• 储存条件: -20°C，干燥，密封

VHL Ligand 3安全信息

• 危害码 (欧洲): Xi

VHL Ligand 3靶点实验

查看更多实验

实验名称：Cytotoxicity against human A2780 cells assessed as reduction in cell viability incuba... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL5509426

实验名称：Cytotoxicity against human HIEC-6 cells assessed as reduction in cell viability incub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5509424

实验名称：Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluoresce... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219881

实验名称：Inhibition of VBC in human HeLa cells assessed as HIF-1alpha stabilization by measuri... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219883

实验名称：Cytotoxicity against human K562 cells assessed as reduction in cell viability incubat... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5509435

实验名称：Cytotoxicity against human COLO 205 cells assessed as reduction in cell viability inc... 来源：ChEMBL 靶标：COLO 205 External Id：CHEMBL5509434

实验名称：Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incu... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5509433

实验名称：Cytotoxicity against human RKO cells assessed as reduction in cell viability incubate... 来源：ChEMBL 靶标：RKO External Id：CHEMBL5509432

实验名称：Cytotoxicity against human LoVo cells assessed as reduction in cell viability incubat... 来源：ChEMBL 靶标：LoVo External Id：CHEMBL5509431

实验名称：Cytotoxicity against human SW480 cells assessed as reduction in cell viability incuba... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL5509430

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VHL Ligand 3英文别名

• 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide