人体重组型神经营养蛋白-4

• 常用名: 人体重组型神经营养蛋白-4
• 英文名: (RS)-3,5-DHPG
• CAS号: 146255-66-5
• 分子量: 183.16100
• 密度: 1.55g/cm3
• 沸点: 448.8ºC at 760mmHg
• 分子式: C₈H₉NO₄
• 熔点: N/A
• 闪点: 225.2ºC

人体重组型神经营养蛋白-4用途

DHPG ((RS)-3,5-DHPG) 是一种氨基酸,为有效、选择性的第一组代谢型谷氨酸受体 mGluR (mGluR 1 和 mGluR 5) 的抑制剂,对第二、三组 mGluR 无明显作用。DHPG ((RS)-3,5-DHPG) 也是与磷脂酶 D 耦合的 mGluR 的有效拮抗剂。

人体重组型神经营养蛋白-4名称

• 中文名: 人体重组型神经营养蛋白-4
• 英文名: (S)-3,5-dihydroxyphenylglycine

人体重组型神经营养蛋白-4生物活性

• 描述: DHPG ((RS)-3,5-DHPG) 是一种氨基酸,为有效、选择性的第一组代谢型谷氨酸受体 mGluR (mGluR 1 和 mGluR 5) 的抑制剂,对第二、三组 mGluR 无明显作用。DHPG ((RS)-3,5-DHPG) 也是与磷脂酶 D 耦合的 mGluR 的有效拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
• 靶点实验:

  mGluR 1

  mGluR 5

• 参考文献:

  [1]. Winder DG, et al. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9.

  [2]. Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43.

人体重组型神经营养蛋白-4物理化学性质

• 密度: 1.55g/cm3
• 沸点: 448.8ºC at 760mmHg
• 分子式: C₈H₉NO₄
• 分子量: 183.16100
• 闪点: 225.2ºC
• 精确质量: 183.05300
• PSA: 103.78000
• LogP: 0.88250
• InChIKey: HOOWCUZPEFNHDT-UHFFFAOYSA-N
• SMILES: NC(C(=O)O)c1cc(O)cc(O)c1
• 储存条件: -20°C，密闭，干燥

人体重组型神经营养蛋白-4靶点实验

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人体重组型神经营养蛋白-4英文别名

• (RS)-3,5-DHPG
• tert-Butylisopentanal
• HEXANAL,3,5,5-TRIMETHYL
• Isononylaldehyde
• 3,5,5-Trimethylcapronaldehyde
• 3,5,5,-trimethylhexanal
• Hexanal,3,5,5-trimethl