Y-29794 oxalate

• 常用名: Y-29794 oxalate
• 英文名: Y-29794 oxalate
• CAS号: 146794-84-5
• 分子量: 508.69
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₆N₂O₅S₂
• 熔点: N/A
• 闪点: N/A

Y-29794 oxalate用途

Y-29794草酸盐是一种选择性、口服活性和血脑屏障可渗透的非肽脯氨酰内肽酶抑制剂。Y-29794草酸盐阻断IRS1-AKT-mTORC1通路并抑制肿瘤生长。Y-29794草酸盐也能有效抑制衰老加速小鼠(SAM)海马中Aβ样沉积的进展[1][2][3]。

Y-29794 oxalate名称

• 英文名: (2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropyl-3-pyridinyl)(2-thienyl)methanone ethanedioate (1:1)

Y-29794 oxalate生物活性

• 描述: Y-29794草酸盐是一种选择性、口服活性和血脑屏障可渗透的非肽脯氨酰内肽酶抑制剂。Y-29794草酸盐阻断IRS1-AKT-mTORC1通路并抑制肿瘤生长。Y-29794草酸盐也能有效抑制衰老加速小鼠(SAM)海马中Aβ样沉积的进展[1][2][3]。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Perez RE, et al. Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Nov 1;21(11):1033-1040.

  [2]. Kato A, et al. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35.

  [3]. Nakajima T, et al. Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141(2):156-60.

Y-29794 oxalate物理化学性质

• 分子式: C₂₅H₃₆N₂O₅S₂
• 分子量: 508.69
• 精确质量: 508.206573
• InChIKey: UUSSHPPSOUAHHP-UHFFFAOYSA-N
• SMILES: CC(C)c1ccc(C(=O)c2cccs2)c(SCCCCCCCCN(C)C)n1.O=C(O)C(=O)O

Y-29794 oxalate靶点实验

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实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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Y-29794 oxalate英文别名

• (2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropyl-3-pyridinyl)(2-thienyl)methanone ethanedioate (1:1)
• Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, ethanedioate (1:1)
• (2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropylpyridin-3-yl)(2-thienyl)methanone ethanedioate (1:1)