Y-29794 oxalate

Modify Date: 2024-01-27 18:17:06

Y-29794 oxalate Structure
Y-29794 oxalate structure
Common Name Y-29794 oxalate
CAS Number 146794-84-5 Molecular Weight 508.69
Density N/A Boiling Point N/A
Molecular Formula C25H36N2O5S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Y-29794 oxalate


Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM)[1][2][3].

 Names

Name (2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropyl-3-pyridinyl)(2-thienyl)methanone ethanedioate (1:1)
Synonym More Synonyms

 Y-29794 oxalate Biological Activity

Description Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM)[1][2][3].
Related Catalog
References

[1]. Perez RE, et al. Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Nov 1;21(11):1033-1040.  

[2]. Kato A, et al. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J Pharmacol Exp Ther. 1997 Oct;283(1):328-35.  

[3]. Nakajima T, et al. Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141(2):156-60.  

 Chemical & Physical Properties

Molecular Formula C25H36N2O5S2
Molecular Weight 508.69
Exact Mass 508.206573

 Synonyms

(2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropyl-3-pyridinyl)(2-thienyl)methanone ethanedioate (1:1)
Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, ethanedioate (1:1)
(2-{[8-(Dimethylamino)octyl]sulfanyl}-6-isopropylpyridin-3-yl)(2-thienyl)methanone ethanedioate (1:1)