QL47

• 常用名: QL47
• 英文名: QL47
• CAS号: 1469988-75-7
• 分子量: 447.488
• 密度: 1.4±0.1 g/cm3
• 沸点: 706.2±60.0 °C at 760 mmHg
• 分子式: C₂₇H₂₁N₅O₂
• 熔点: N/A
• 闪点: 380.9±32.9 °C

QL47用途

QL47不可逆的BTK抑制剂,IC50为7 nM。

QL47名称

• 中文名: QL47
• 英文名: QL47

QL47生物活性

• 描述: QL47不可逆的BTK抑制剂,IC50为7 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
  研究领域 >> 癌症
• 参考文献:

  [1]. Wu, H., et al., Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma. ACS Chem Biol, 2014.

QL47物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 706.2±60.0 °C at 760 mmHg
• 分子式: C₂₇H₂₁N₅O₂
• 分子量: 447.488
• 闪点: 380.9±32.9 °C
• 精确质量: 447.169525
• LogP: 2.50
• InChIKey: RTRNJQOBEOISFQ-UHFFFAOYSA-N
• SMILES: C=CC(=O)N1CCc2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnn(C)c6)cc5c43)cc21
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.724
• 储存条件: 2-8℃

QL47靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Antiviral activity against Respiratory syncytial virus A2 infected in Vero cells at 2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4043021

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Antiviral activity against West Nile virus Kunjin infected in HuH7 cells at 2 uM meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4043022

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Antiviral activity against Polio virus Chat infected in Vero cells at 4 uM measured a... 来源：ChEMBL 靶标：Enterovirus C External Id：CHEMBL4043019

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QL47英文别名

• 1-(1-Acryloyl-2,3-dihydro-1H-indol-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one
• 9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone