匹伐他汀

• 常用名: 匹伐他汀
• 英文名: Pitavastatin
• CAS号: 147511-69-1
• 分子量: 421.461
• 密度: 1.4±0.1 g/cm3
• 沸点: 692.0±55.0 °C at 760 mmHg
• 分子式: C₂₅H₂₄FNO₄
• 熔点: N/A
• 闪点: 372.3±31.5 °C

匹伐他汀用途

Pitavastatin (NK-104)是HMG-CoA还原酶抑制剂,能抑制从醋酸到胆固醇的合成,IC50为5.8 nM。

匹伐他汀名称

• 中文名: 匹伐他汀
• 英文名: pitavastatin
• 中文别名: (3R,5S,6E)-7-(2-环丙基-4-(4-氟苯基)喹啉-3-基)-3,5-二羟基庚-6-烯酸 | 匹伐他汀酸

匹伐他汀生物活性

• 描述: Pitavastatin (NK-104)是HMG-CoA还原酶抑制剂,能抑制从醋酸到胆固醇的合成,IC50为5.8 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44.

  [2]. Katsuki S, et al. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 2014 Feb 25;129(8):896-906.

  [3]. Tajiri K, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24.

  [4]. Hamano T, et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiol Aging. 2012 Oct;33(10):2306-20.

匹伐他汀物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 692.0±55.0 °C at 760 mmHg
• 分子式: C₂₅H₂₄FNO₄
• 分子量: 421.461
• 闪点: 372.3±31.5 °C
• 精确质量: 421.168945
• PSA: 90.65000
• LogP: 3.45
• InChIKey: VSQHXQMFUCHGBD-NRFPMOEYSA-N
• SMILES: O=C(O)CC(O)CC(O)C=Cc1c(C2CC2)nc2ccccc2c1-c1ccc(F)cc1.[Ca+2]
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.680
• 储存条件: 2-8℃

匹伐他汀安全信息

• 危害码 (欧洲): Xi
• 海关编码: 3004909090

匹伐他汀海关

• 海关编码: 3004909090

匹伐他汀靶点实验

查看更多实验

实验名称：Rat hydroxymethylglutaryl-CoA reductase (Lanosterol biosynthesis pathway) 来源：IUPHAR-DB 靶标：hydroxymethylglutaryl-CoA reductase (Lanosterol biosynthesis pathway) [Rattus norvegicus] External Id：639_Rat

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：TP_TRANSPORTER: cell accumulation in OATP2-expressing HEK293 cells 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL2076471

实验名称：Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay 来源：24386 靶标：N/A External Id：Sarm1 Tir NADase inhibitors screen

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

实验名称：Binding affinity towards human CNR1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291773

实验名称：Binding affinity towards human MC4R in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Melanocortin receptor 4 External Id：CHEMBL5291832

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匹伐他汀英文别名

• ITAVASTATIN
• Pitavastatin
• (6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
• PITVASTATIN
• MFCD04113054