醋酸依替巴肽

• 常用名: 醋酸依替巴肽
• 英文名: Eptifibatide Acetate
• CAS号: 148031-34-9
• 分子量: 831.962
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₃₅H₄₉N₁₁O₉S₂
• 熔点: 92-98 °C
• 闪点: N/A

醋酸依替巴肽用途

Eptifibatide, also co-promoted by Schering-Plough/Essex, is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

醋酸依替巴肽名称

• 中文名: 埃替非巴肽
• 英文名: Eptifibatide
• 中文别名: 安普利肽 | 醋酸安普利肽 | 依非巴特醋酸盐 | 醋酸依非巴特 | 醋酸依替巴肽

醋酸依替巴肽物理化学性质

• 密度: 1.6±0.1 g/cm3
• 熔点: 92-98 °C
• 分子式: C₃₅H₄₉N₁₁O₉S₂
• 分子量: 831.962
• 精确质量: 831.315613
• PSA: 374.49000
• LogP: -4.84
• InChIKey: CZKPOZZJODAYPZ-UHFFFAOYSA-N
• SMILES: NC(=O)C1CSSCCC(=O)NC(CCCCN=C(N)N)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)N2CCCC2C(=O)N1
• 外观性状: 白色粉末
• 折射率: 1.735
• 储存条件: 2-8°C
• 分子结构:

  1、摩尔折射率：208.03

  2、摩尔体积（cm³/mol）：518.4

  3、等张比容（90.2K）：1530.5

  4、表面张力（dyne/cm）：75.9

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：82.47

  7、单一同位素质量：831.315612 Da

  8、标称质量：831 Da

  9、平均质量：831.9619 Da

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-2.4

  2.氢键供体数量:10

  3.氢键受体数量:12

  4.可旋转化学键数量:10

  5.互变异构体数量:1000

  6.拓扑分子极性表面积377

  7.重原子数量:57

  8.表面电荷:0

  9.复杂度:1520

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:5

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

醋酸依替巴肽安全信息

• 危害码 (欧洲): Xi,Xn
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin . R22:Harmful if swallowed.
• 安全声明 (欧洲): S26-S36/37/39
• 危险品运输编码: UN 2811 6.1/PG 3

醋酸依替巴肽靶点实验

查看更多实验

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：ULK1_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：HTS to identify compounds that affect the blood-brain barrier permeability in vitro 来源：26908 靶标：N/A External Id：HTS97080

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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醋酸依替巴肽英文别名

• n6-(aminoiminomethyl)-n2-(3-mercapto-1-oxopropyl-l-lysylglycyl-l-a-aspartyl-l-tryptophyl-l-prolyl-l-cysteinamide
• Mpr-Harg-Gly-Asp-Trp-Pro-Cys-NH2,( Disulfide Bridge:1-7)
• EFTIFIBATIDE
• MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2
• MFCD05662245
• [11-(4-Carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
• Mpr-Harg-Gly-Asp-Trp-Pro-Cys-NH2,( Disulfide Bridg on Mpr and Cys)
• Eptifitide
• INTEGRELIN
• Eptifibatide Acetate