NaV1.7抑制剂-1

• 常用名: NaV1.7抑制剂-1
• 英文名: NaV1.7 inhibitor-1
• CAS号: 1494585-79-3
• 分子量: 435.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₀FNO₄S
• 熔点: N/A
• 闪点: N/A

NaV1.7抑制剂-1用途

NaV1.7 inhibitor-1 是一种有效的电压门控钠通道 (Nav) 1.7 抑制剂,对于 hNaV1.7 的 IC50 值为 0.6 nM,其选择性是 hNaV1.5 的 80 倍。

NaV1.7抑制剂-1名称

• 中文名: NaV1.7抑制剂-1
• 英文名: NaV1.7 inhibitor-1

NaV1.7抑制剂-1生物活性

• 描述: NaV1.7 inhibitor-1 是一种有效的电压门控钠通道 (Nav) 1.7 抑制剂,对于 hNaV1.7 的 IC50 值为 0.6 nM,其选择性是 hNaV1.5 的 80 倍。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 0.6 nM (hNaV1.7)[1]

• 参考文献:

  [1]. Sun S, Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-GatedSodium Channel (NaV) 1.7 with Potent Analgesic Activity. J Med Chem. 2019 Jan 24;62(2):908-927.

NaV1.7抑制剂-1物理化学性质

• 分子式: C₂₃H₃₀FNO₄S
• 分子量: 435.55
• InChIKey: GFDXIUXAFNREKM-UHFFFAOYSA-N
• SMILES: CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2

NaV1.7抑制剂-1靶点实验

查看更多实验

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.5 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322002

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.2 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4321999

实验名称：Selectivity index, ratio of IC50 for inhibition of human Nav1.1 expressed in HEK293 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4321998

实验名称：Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 8 subunit alpha External Id：CHEMBL4321996

实验名称：Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL4321995

实验名称：Unbound fraction in mouse plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322009

实验名称：Ratio of unbound plasma concentration in mouse model of inherited erythromelalgia to ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322008

实验名称：Ratio of unbound plasma concentration in mouse model of formalin-induced pain to IC50... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322007

实验名称：Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 9 subunit alpha External Id：CHEMBL4322006

实验名称：Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay 来源：ChEMBL 靶标：Sodium channel protein type 9 subunit alpha External Id：CHEMBL4322005

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