曲韦定

• 常用名: 曲韦定
• 英文名: Trovirdine
• CAS号: 149488-17-5
• 分子量: 337.23800
• 密度: 1.539g/cm3
• 沸点: 450.6ºC at 760mmHg
• 分子式: C₁₃H₁₃BrN₄S
• 熔点: N/A
• 闪点: N/A

曲韦定用途

Trovirdine抑制HIV-1逆转录, IC50为7 nM。

曲韦定名称

• 中文名: 曲韦定
• 英文名: Trovirdine

曲韦定生物活性

• 描述: Trovirdine抑制HIV-1逆转录, IC50为7 nM。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127.

  [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.

曲韦定物理化学性质

• 密度: 1.539g/cm3
• 沸点: 450.6ºC at 760mmHg
• 分子式: C₁₃H₁₃BrN₄S
• 分子量: 337.23800
• 精确质量: 336.00400
• PSA: 81.93000
• LogP: 3.23210
• InChIKey: HOCFDYZWQYGULA-UHFFFAOYSA-N
• SMILES: S=C(NCCc1ccccn1)Nc1ccc(Br)cn1
• 外观性状: light yellow solid
• 蒸汽压: 2.61E-08mmHg at 25°C
• 折射率: 1.696
• 储存条件: -20℃

曲韦定靶点实验

查看更多实验

实验名称：Ability to inhibit the replication of A17 variant (Y181C,K103N) strain of HIV-1 p24 a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL757559

实验名称：Tested for the inhibition of wild type HIV-1 (IIIB) RT 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL800602

实验名称：Ability to inhibit the replication of the NNI-sensitive/AZT-sensitive HIV-1 strain HT... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL684474

实验名称：Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL800601

实验名称：HIV-1 RT Assay from Article 10.1021/jm00025a010: "Phenethylthiazolethiourea (PETT) co... 来源：BindingDB 靶标：N/A External Id：BindingDB_399_1

实验名称：Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL800600

实验名称：Ability to inhibit the replication of HTLV IIIb strain of HIV-1 p24 antigen productio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL757561

实验名称：Ability to inhibit the replication of RT-MDR (V106A) strain of HIV-1 p24 antigen prod... 来源：ChEMBL 靶标：N/A External Id：CHEMBL757562

实验名称：Anti-HIV activity by its ability to inhibit the replication of HIV-1 strain HTLV IIIB... 来源：ChEMBL 靶标：N/A External Id：CHEMBL757567

实验名称：Anti-HIV activity by its ability to inhibit the replication of HIV-1 strain A17 varia... 来源：ChEMBL 靶标：N/A External Id：CHEMBL757565

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曲韦定英文别名

• Thiourea,N-(5-bromo-2-pyridinyl)-N'-[2-(2-pyridinyl)ethyl]
• Hi-142
• LY-300046