Ro 46-2005

• 常用名: Ro 46-2005
• 英文名: Ro 46-2005
• CAS号: 150725-87-4
• 分子量: 473.542
• 密度: 1.3±0.1 g/cm3
• 沸点: 617.5±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₃O₆S
• 熔点: N/A
• 闪点: 327.3±34.3 °C

Ro 46-2005用途

Ro 46-2005是一种新型非肽类内皮素拮抗剂, 抑制人血管平滑肌细胞(ETA受体), IC50分别为220 nM。

Ro 46-2005名称

• 中文名: Ro 46-2005
• 英文名: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide

Ro 46-2005生物活性

• 描述: Ro 46-2005是一种新型非肽类内皮素拮抗剂, 抑制人血管平滑肌细胞(ETA受体), IC50分别为220 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 内皮素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Breu V, et al. In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETBreceptors. FEBS Lett. 1993 Nov 15;334(2):210-214.

  [2]. Clozel M, et al. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature. 1993 Oct 21;365(6448):759-761.

  [3]. N.R. Sibson, et al. MRI Determination of the Mechanisms Underlying TNF-a-induced Changes in Cerebral Blood Volume, Tissue Water Diffusion and BBB Permeability. Proc. Intl. Soc. Mag. Reson. Med. 10 (2002)

Ro 46-2005物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 617.5±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₃O₆S
• 分子量: 473.542
• 闪点: 327.3±34.3 °C
• 精确质量: 473.162048
• PSA: 128.25000
• LogP: 2.22
• InChIKey: ZNXOKLWCOWOECF-UHFFFAOYSA-N
• SMILES: COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.593
• 储存条件: 2-8℃

Ro 46-2005靶点实验

查看更多实验

实验名称：In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothel... 来源：ChEMBL 靶标：Endothelin receptor type B External Id：CHEMBL846852

实验名称：In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothel... 来源：ChEMBL 靶标：Endothelin receptor type B External Id：CHEMBL846854

实验名称：In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothel... 来源：ChEMBL 靶标：Endothelin receptor type B External Id：CHEMBL846853

实验名称：Ability to protect rats from ET-1 induced sudden death in rats after peroral administ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL823617

实验名称：In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic m... 来源：ChEMBL 靶标：Endothelin-1 receptor External Id：CHEMBL679705

实验名称：Delta logD (pH 6.5) 来源：ChEMBL 靶标：N/A External Id：CHEMBL626838

实验名称：Partition coefficient by standard shake-flask techniquesat 37 C, using octanol and cy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL626839

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Ro 46-2005英文别名

• N-[6-(2-Hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-4-(2-methyl-2-propanyl)benzenesulfonamide
• Ro 46-2005
• 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide