GT 2016

• 常用名: GT 2016
• 英文名: GT 2016
• CAS号: 152241-24-2
• 分子量: 317.46900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₃₁N₃O
• 熔点: N/A
• 闪点: N/A

GT 2016用途

GT-2016是一种有效、选择性和脑渗透性组胺H3受体拮抗剂,Ki为43.8 nM。GT-2016对H1和H2受体有选择性,对组胺甲基转移酶无活性[1]。

GT 2016名称

• 英文名: 5-Cyclohexyl-1-[4-(1H-imidazol-5-yl)-1-piperidinyl]-1-pentanone

GT 2016生物活性

• 描述: GT-2016是一种有效、选择性和脑渗透性组胺H3受体拮抗剂,Ki为43.8 nM。GT-2016对H1和H2受体有选择性,对组胺甲基转移酶无活性[1]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点实验:

  H3 Receptor:43.8 nM (Ki)

• 参考文献:

  [1]. C E Tedford, et al. Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies. J Pharmacol Exp Ther. 1995 Nov;275(2):598-604.

GT 2016物理化学性质

• 分子式: C₁₉H₃₁N₃O
• 分子量: 317.46900
• 精确质量: 317.24700
• PSA: 48.99000
• LogP: 4.19430
• InChIKey: YTCGNPGLMAECND-UHFFFAOYSA-N
• SMILES: O=C(CCCCC1CCCCC1)N1CCC(c2cnc[nH]2)CC1

GT 2016靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Histamine H3 receptor affinity of compound was determined in rat cortical membranes u... 来源：ChEMBL 靶标：Histamine H3 receptor External Id：CHEMBL698406

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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GT 2016英文别名

• Grifolic acid