MAO-B-IN-19

• 常用名: MAO-B-IN-19
• 英文名: MAO-B-IN-19
• CAS号: 152897-41-1
• 分子量: 242.25
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₁FO₂
• 熔点: N/A
• 闪点: N/A

MAO-B-IN-19用途

MAO-B-IN-19是一种选择性MAO-B抑制剂,IC50为0.67μM。MAO-B-IN-19具有神经保护和抗炎特性[1]。

MAO-B-IN-19名称

• 英文名: MAO-B-IN-19

MAO-B-IN-19生物活性

• 描述: MAO-B-IN-19是一种选择性MAO-B抑制剂,IC50为0.67μM。MAO-B-IN-19具有神经保护和抗炎特性[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  MAO-B:0.67 μM (IC50)

• 体外研究: 毛(化合物 3f)显着抑制自身诱导的 Aβ1-42聚集,并对 Aβ25-35诱导的 PC12细胞损伤显示出显着的神经保护作用。毛是一种选择性金属螯合剂,可以抑制 Cu2+诱导的 Aβ1-42聚集[1]
• 参考文献:

  [1]. Rui Chen, et al. Development of the "hidden" multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 May 5;251:115253.

MAO-B-IN-19物理化学性质

• 分子式: C₁₅H₁₁FO₂
• 分子量: 242.25
• InChIKey: BGVXUADKPAJQBF-JXMROGBWSA-N
• SMILES: O=C(C=Cc1ccc(F)cc1)c1ccccc1O

MAO-B-IN-19靶点实验

查看更多实验

实验名称：Cytotoxicity in mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTS a... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3997012

实验名称：Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3997011

实验名称：Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MT... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL2405440

实验名称：Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability at 10 u... 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL5349222

实验名称：Selectivity index, ratio of IC50 for inhibition of human recombinant MAO-A expressed ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5349219

实验名称：Inhibition of self-induced Amyloid beta (1 to 42) (unknown origin) aggregation at 25 ... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL5349220

实验名称：Inhibition of human recombinant MAO-A expressed in baculovirus-infected BTI cells usi... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL5349217

实验名称：Antifungal activity against fluconazole-resistant Candida albicans clinical isolate 1... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3813069

实验名称：Inhibition of human recombinant MAO-B expressed in baculovirus-infected BTI cells usi... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL5349218

实验名称：Cytotoxicity against human HCT116 cells assessed as cell viability at 10 uM after 48 ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL2405442

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