Gavestinel

• 常用名: Gavestinel
• 英文名: Gavestinel
• CAS号: 153436-38-5
• 分子量: 397.19
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₁Cl₂N₂NaO₃
• 熔点: N/A
• 闪点: N/A

Gavestinel用途

Gavestinel(GV 150526)是一种有效、选择性、口服活性和非竞争性的NMDA受体拮抗剂。Gavestinel与NMDA受体的甘氨酸位点结合,pKi为8.5。Gavestinel可用于急性缺血性卒中的研究[1]。

Gavestinel名称

• 英文名: sodium,3-[(E)-3-anilino-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylate

Gavestinel生物活性

• 描述: Gavestinel(GV 150526)是一种有效、选择性、口服活性和非竞争性的NMDA受体拮抗剂。Gavestinel与NMDA受体的甘氨酸位点结合,pKi为8.5。Gavestinel可用于急性缺血性卒中的研究[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点实验:

  pKi: 8.5 (NMDA receptor)[1]

• 参考文献:

  [1]. Fabio RD, et, al. Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J Med Chem. 1997 Mar 14;40(6):841-50.

Gavestinel物理化学性质

• 分子式: C₁₈H₁₁Cl₂N₂NaO₃
• 分子量: 397.19
• 精确质量: 396.00400
• PSA: 88.51000
• LogP: 5.34680
• InChIKey: GRSDSTMFQHAESM-UHDJGPCESA-M
• SMILES: O=C(C=Cc1c(C(=O)[O-])[nH]c2cc(Cl)cc(Cl)c12)Nc1ccccc1.[Na+]
• 储存条件: -20°C， 密封， 干燥

Gavestinel靶点实验

查看更多实验

实验名称：Binding to rat serum albumin 来源：ChEMBL 靶标：Albumin External Id：CHEMBL644569

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：In vivo effective dose of compound to protect mice from quinolinic acid seizures upon... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL834101

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：In vivo effective dose to protect the mouse (DBA/2J) from audiogenic seizures upon in... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL834191

实验名称：Reduction in infarct volume in rat with proximal middle cerebral artery occlusion at ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL874230

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Inhibition of NMDA-induced convulsions in mice by the compound when administered by i... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL720236

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Inhibition of [3H]glycine binding to N-methyl-D-aspartate glutamate receptor in synap... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 3A External Id：CHEMBL748772

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Gavestinel英文别名

• UNII-80W7787JVB
• 4,6-dichloro-3-((1E)-3-oxo-3-(phenylamino)-1-propenyl)-1H-indole-2-carboxylic acid sodium salt
• Gavestinel sodium