Prunetrin

• 常用名: Prunetrin
• 英文名: Prunetrin
• CAS号: 154-36-9
• 分子量: 446.40400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₂O₁₀
• 熔点: N/A
• 闪点: N/A

Prunetrin用途

Prunetin (Trifoside) 是一种在紫李中发现的 O-甲基化异黄酮,具有抗炎活性。

Prunetrin名称

• 英文名: 3-{4-[(2S,4S,5S,3R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]phenyl}-5-hydroxy-7-methoxychromen-4-one

Prunetrin生物活性

• 描述: Prunetin (Trifoside) 是一种在紫李中发现的 O-甲基化异黄酮,具有抗炎活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 夏枯草素通过在转录水平上抑制iNOS和COX-2来抑制LPS诱导的一氧化氮和前列腺素E2的产生[1]。夏枯草素抑制脂多糖诱导的炎症细胞因子的产生和MUC5AC的表达,方法是使TLR4/MyD88通路失活[2]。
• 参考文献:

  [1]. Yang G, et al. Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway. Food Chem Toxicol. 2013;58:124-132.

  [2]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018;106:1469-1477.

Prunetrin物理化学性质

• 分子式: C₂₂H₂₂O₁₀
• 分子量: 446.40400
• 精确质量: 446.12100
• PSA: 159.05000
• LogP: 0.35290
• InChIKey: OFUWGCQDMVDLIR-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(=O)c(-c3ccc(OC4OC(CO)C(O)C(O)C4O)cc3)coc2c1

Prunetrin靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of NR3A 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1015-NR3A-Primary-Assay

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Prunetrin英文别名

• 3-(4-β-D-glucopyranosyloxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one
• 5-Hydroxy-7-methoxy-3-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chromen-4-one
• prunetin-4'-O-β-D glucopyranoside
• prunetrin
• Prunetin 4'-O-β-D-glucopyranoside
• prunetin 4'-O-[β-D-glucopyranoside]
• 4',5-dihydroxy-7-methoxyisoflavone-4'-O-β-D-glucopyranoside