ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)

更新时间：2025-08-24 00:00:34

ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)结构式	常用名	ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)	英文名	Uroguanylin Topoisomer A (human) trifluoroacetate salt
	CAS号	154525-25-4	分子量	1667.86000
	密度	N/A	沸点	N/A
	分子式	C₆₄H₁₀₂N₁₈O₂₆S₄	熔点	N/A
	MSDS	中文版美版	闪点	N/A

用途

Uroguanylin (human) 是在转移性结直肠癌肿瘤中表达的观音酰环化酶(GCC)受体的天然配体。Guanylyl Cyclase 在人结肠癌动物模型具有抗肿瘤作用。

中文名	ASN-ASP-ASP-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BRIDGE: CYS4-CYS12,CYS7-CYS15)
英文名	asn-asp-asp-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu
英文别名	更多

描述	Uroguanylin (human) 是在转移性结直肠癌肿瘤中表达的观音酰环化酶(GCC)受体的天然配体。Guanylyl Cyclase 在人结肠癌动物模型具有抗肿瘤作用。
相关类别	研究领域 >> 癌症信号通路 >> G 蛋白偶联受体/G 蛋白 >> 鸟苷酸环化酶
参考文献	[1]. Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130(1-2):101-108.

分子式	C₆₄H₁₀₂N₁₈O₂₆S₄
分子量	1667.86000
精确质量	1666.61000
PSA	819.33000
InChIKey	VQZRYOAXGUCZMI-HWMZBCIHSA-N
SMILES	CC(C)CC(NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(N)CC(N)=O)CSSCC(NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC2=O)C(=O)NC(C(C)O)C(=O)NCC(=O)N1)C(=O)O

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin.

Infect. Immun. 82(7) , 2913-22, (2014)

Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh] and porcine-type [STp] variants) is among the five most important enteric pathogens in young children li...

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

J. Clin. Invest. 121 , 3578-3588, (2011)

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting...

Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.

Proc. Natl. Acad. Sci. U. S. A. 90 , 10464, (1993)

The intestinal hormone guanylin and bacterial heat-stable enterotoxins (STs) are members of a peptide family that activates intestinal membrane guanylate cyclase. Two different peptides that activate ...