BRD3308

• 常用名: BRD3308
• 英文名: BRD3308
• CAS号: 1550053-02-5
• 分子量: 287.289
• 密度: 1.4±0.1 g/cm3
• 沸点: 449.9±45.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄FN₃O₂
• 熔点: N/A
• 闪点: 225.9±28.7 °C

BRD3308用途

BRD3308是一种有效的选择性HDAC3抑制剂,IC50为54 nM,选择性比HDAC1和HDAC2高20倍,选择性比其他HDAC同种型高500倍；减弱PE介导的ERK磷酸化,但不减弱JNK；也激活2D10细胞系中的HIV-1转录,从体外抗逆转录病毒治疗的禽流感HIV+患者中分离的静息CD4+T细胞诱导HIV-1生长并破坏HIV-1潜伏期；抑制由炎性细胞因子或糖脂毒性应激诱导的胰腺β细胞凋亡,并增加功能性胰岛素释放。

BRD3308名称

• 英文名: BRD3308

BRD3308生物活性

• 描述: BRD3308是一种有效的选择性HDAC3抑制剂,IC50为54 nM,选择性比HDAC1和HDAC2高20倍,选择性比其他HDAC同种型高500倍；减弱PE介导的ERK磷酸化,但不减弱JNK；也激活2D10细胞系中的HIV-1转录,从体外抗逆转录病毒治疗的禽流感HIV+患者中分离的静息CD4+T细胞诱导HIV-1生长并破坏HIV-1潜伏期；抑制由炎性细胞因子或糖脂毒性应激诱导的胰腺β细胞凋亡,并增加功能性胰岛素释放。
• 参考文献: References 1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11. 2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684. 3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74. View Related Products by Target HDAC

BRD3308物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 449.9±45.0 °C at 760 mmHg
• 分子式: C₁₅H₁₄FN₃O₂
• 分子量: 287.289
• 闪点: 225.9±28.7 °C
• 精确质量: 287.106995
• LogP: 1.81
• InChIKey: RRJDFENBXIEAPD-UHFFFAOYSA-N
• SMILES: CC(=O)Nc1ccc(C(=O)Nc2ccc(F)cc2N)cc1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.689
• 储存条件: -20°C，密闭，干燥

BRD3308靶点实验

查看更多实验

实验名称：Selectivity index, ratio of IC50 for Inhibition of human HDAC3 to Inhibition of human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5325171

实验名称：Selectivity index, ratio of IC50 for Inhibition of human HDAC3 to IC50 for Inhibition... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5325170

实验名称：Inhibition of Histone Deacetylase Enzymatic Activity from US Patent US11377423: "Inhi... 来源：BindingDB 靶标：N/A External Id：BindingDB_10691_1

实验名称：Selectivity ratio of IC50 for HDAC1 (unknown origin) to IC50 for HDAC3 (unknown origi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4275638

实验名称：Binding affinity to human HDAC2 assessed as residence time 来源：ChEMBL 靶标：Histone deacetylase 2 External Id：CHEMBL5325165

实验名称：Binding affinity to human HDAC3 assessed as residence time 来源：ChEMBL 靶标：Histone deacetylase 3 External Id：CHEMBL5325166

实验名称：Selectivity ratio of IC50 for HDAC2 (unknown origin) to IC50 for HDAC3 (unknown origi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4275639

实验名称：Binding affinity to human HDAC1 assessed as residence time 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL5325164

实验名称：Binding affinity to human HDAC2 assessed as half life 来源：ChEMBL 靶标：Histone deacetylase 2 External Id：CHEMBL5325159

实验名称：Binding affinity to human HDAC3 assessed as half life 来源：ChEMBL 靶标：Histone deacetylase 3 External Id：CHEMBL5325160

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BRD3308英文别名

• BRD3308
• 4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide
• MFCD30187588