moiramide B

• 常用名: moiramide B
• 英文名: moiramide B
• CAS号: 155233-31-1
• 分子量: 453.531
• 密度: 1.2±0.1 g/cm3
• 沸点: 772.9±60.0 °C at 760 mmHg
• 分子式: C₂₅H₃₁N₃O₅
• 熔点: N/A
• 闪点: 238.5±33.0 °C

moiramide B用途

Moiramide B是一种有效的乙酰辅酶a羧化酶(ACC)抑制剂,IC50值为6nM。Moiramide B具有抗菌活性[1]。

moiramide B名称

• 英文名: moiramide B

moiramide B生物活性

• 描述: Moiramide B是一种有效的乙酰辅酶a羧化酶(ACC)抑制剂,IC50值为6nM。Moiramide B具有抗菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: Moiramide B(化合物3；0.012-25μM；大肠杆菌)具有抗菌活性,对于 WT、WT+PMBN、ΔacrAB、ΔacrAB+PMBN、ΔtolC和 ΔtolC+PMBN的 麦克风值分别为 >25、3.13、25、0.39、1.56、和 0.1μM[1]
• 参考文献:

  [1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525.

moiramide B物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 772.9±60.0 °C at 760 mmHg
• 分子式: C₂₅H₃₁N₃O₅
• 分子量: 453.531
• 闪点: 238.5±33.0 °C
• 精确质量: 453.226379
• LogP: 2.25
• InChIKey: WMLLJSBRSSYYPT-UHFFFAOYSA-N
• SMILES: CC=CC=CC(=O)NC(CC(=O)NC(C(=O)C1C(=O)NC(=O)C1C)C(C)C)c1ccccc1
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.548

moiramide B靶点实验

查看更多实验

实验名称：Displacement of 11-(4-(22-(2,4-dibromo-3-(2,7-diaminopyrido[2,3-d]pyrimidin-6-yl)phen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5239369

实验名称：Antibacterial activity against tolC knockout Escherichia coli incubated for 24 hrs in... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239366

实验名称：Antibacterial activity against tolC knockout Escherichia coli incubated for 24 hrs by... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239365

实验名称：Synergistic antibacterial activity against Escherichia coli harbouring TolC-deficient... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239368

实验名称：Additive antibacterial activity against Escherichia coli harbouring TolC-deficient mu... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239367

实验名称：Antibacterial activity against Escherichia coli incubated for 24 hrs in presence of P... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239362

实验名称：Antibacterial activity against Escherichia coli K12 incubated for 24 hrs by microbrot... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239361

实验名称：Antibacterial activity against acrAB knockout Escherichia coli MG1655 incubated for 2... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239364

实验名称：Antibacterial activity against acrAB knockout Escherichia coli MG1655 incubated for 2... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5239363

实验名称：Inhibition of Escherichia coli ACC expressed in Escherichia coli BL21(DE3) pLysS incu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5239360

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moiramide B英文别名

• (2E,4E)-N-[(1S)-3-({(2S)-3-Methyl-1-[(3R,4S)-4-methyl-2,5-dioxo-3-pyrrolidinyl]-1-oxo-2-butanyl}amino)-3-oxo-1-phenylpropyl]-2,4-hexadienamide
• moiramide B
• (2E,4E)-N-[(1S)-3-({(2S)-3-methyl-1-[(3R,4S)-4-methyl-2,5-dioxopyrrolidin-3-yl]-1-oxobutan-2-yl}amino)-3-oxo-1-phenylpropyl]hexa-2,4-dienamide