Sograzepide

• 常用名: Sograzepide
• 英文名: Sograzepide
• CAS号: 155488-25-8
• 分子量: 498.57600
• 密度: 1.25g/cm3
• 沸点: 723.049ºC at 760 mmHg
• 分子式: C₂₈H₃₀N₆O₃
• 熔点: N/A
• 闪点: 391.086ºC

Sograzepide用途

Sograzepide (Netazepide;YF476) 是一种胃泌素/缩胆囊素2受体 (gastrin/cholecystokinin 2 receptor (CCK2)) 拮抗剂。

Sograzepide名称

• 中文名: N-[(3R)-1-(3,3-二甲基-2-氧代丁基)-2,3-二氢-2-氧代-5-(2-吡啶基)-1H-1,4-苯并二氮杂卓-3-基]-N’-[3-(甲基氨基)苯基]脲
• 英文名: 1-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea

Sograzepide生物活性

• 描述: Sograzepide (Netazepide;YF476) 是一种胃泌素/缩胆囊素2受体 (gastrin/cholecystokinin 2 receptor (CCK2)) 拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胆囊收缩素受体
  研究领域 >> 代谢疾病
• 靶点实验:

  Gastrin/cholecystokinin 2 receptor (CCK2)[1]

• 参考文献:

  [1]. Boyce M, et al. Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects. Br J Clin Pharmacol. 2015 May;79(5):744-55.

Sograzepide物理化学性质

• 密度: 1.25g/cm3
• 沸点: 723.049ºC at 760 mmHg
• 分子式: C₂₈H₃₀N₆O₃
• 分子量: 498.57600
• 闪点: 391.086ºC
• 精确质量: 498.23800
• PSA: 119.28000
• LogP: 4.04840
• InChIKey: YDZYKNJZCVIKPP-VWLOTQADSA-N
• SMILES: CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1
• 储存条件: 2-8℃

Sograzepide靶点实验

查看更多实验

实验名称：Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition o... 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL889352

实验名称：Ratio of inhibitory concentration; CCK-A receptor to CCK-B receptor 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL848619

实验名称：Inhibition of pentagastrin-stimulated gastric acid secretion in conscious gastric fis... 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL889354

实验名称：Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid sec... 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL859934

实验名称：Inhibition of pentagastrin-stimulated gastric acid secretion in conscious gastric fis... 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL889355

实验名称：Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T... 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL889348

实验名称：Antagonist activity at CCK2 receptor in stomach-lumen perfused immature rat 来源：ChEMBL 靶标：Gastrin/cholecystokinin type B receptor External Id：CHEMBL944976

实验名称：Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic ... 来源：ChEMBL 靶标：Cholecystokinin receptor type A External Id：CHEMBL944977

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Displacement of [3H]L-364718 from human recombinant CCK1 receptor expressed in CHOK1 ... 来源：ChEMBL 靶标：Cholecystokinin receptor type A External Id：CHEMBL889351

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Sograzepide英文别名

• UNII-HOU4I0G29C
• YF-476
• Sograzepide