LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2

• 常用名: LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2
• 英文名: Cecropin A (1-7)-Melittin A (2-9) amide trifluoroacetate salt
• CAS号: 157606-25-2
• 分子量: 1770.30000
• 密度: N/A
• 沸点: N/A
• 分子式: C₈₉H₁₅₂N₂₂O₁₅
• 熔点: N/A
• 闪点: N/A

用途

Cecropin A(1-7)-蜂毒肽A(2-9)是一种抗微生物肽,对广泛的革兰氏阳性和革兰氏阴性需氧菌具有抗菌活性,并具有抗疟活性,没有蜂毒肽的不利溶血特性[1]。

名称

• 中文名: LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2
• 英文名: cecropin a (1-7)-melittin a (2-9) amide

生物活性

• 描述: Cecropin A(1-7)-蜂毒肽A(2-9)是一种抗微生物肽,对广泛的革兰氏阳性和革兰氏阴性需氧菌具有抗菌活性,并具有抗疟活性,没有蜂毒肽的不利溶血特性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: Cecropin A(1-7)-蜂毒肽A(2-9)(0-64 mg/L,48小时)作用于E、 大肠杆菌ATCC 25922、金黄色葡萄球菌ATCC 29213、脆弱芽孢杆菌NCTC 9343和 C、 白流苏ATCC 13124的 麦克风值分别为 8 mg/L、32 mg/L、8 mg/L和64 mg/L[1]
• 参考文献:

  [1]. Charlotta Edlund, et al. Antianaerobic activity of a cecropin---melittin peptide. Clin Microbiol Infect. 1998 Apr;4(4):181-185.

物理化学性质

• 分子式: C₈₉H₁₅₂N₂₂O₁₅
• 分子量: 1770.30000
• 精确质量: 1769.18000
• PSA: 622.40000
• LogP: 10.72030
• InChIKey: WMTUWZOBAVPERW-VZYQMWHSSA-N
• SMILES: CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(N)CCCCN)C(=O)NCC(=O)NC(C)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(N)=O)C(C)C)C(C)C

靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as reduction... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5130210

实验名称：Stability of compound assessed as trypsin (unknown origin)-mediated compound degradat... 来源：ChEMBL 靶标：Trypsin-3 External Id：CHEMBL5339253

实验名称：Chemical stability assessed as degradation after 1 hr 来源：ChEMBL 靶标：N/A External Id：CHEMBL1217629

实验名称：Antibacterial activity against Bacillus subtilis ATCC 6051 assessed as reduction in b... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL5130211

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in b... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5339250

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 25932 assessed as reduction... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5339251

实验名称：Hemolytic activity in sheep RBC assessed as hemolysis incubated for 30 mins by microp... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL5130213

实验名称：Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability at 1... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5339248

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in b... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5130208

实验名称：Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability meas... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5339247

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英文别名

• H-LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2
• CECROPIN A-MELITTIN HYBRID PEPTIDE
• LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2
• KWKLFKKIGAVLKVL-NH2
• KWKLFKKIGAVLKVL-amide