Atuzabrutinib

• 常用名: Atuzabrutinib
• 英文名: atuzabrutinib
• CAS号: 1581714-49-9
• 分子量: 539.60
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₀FN₇O₂
• 熔点: N/A
• 闪点: N/A

Atuzabrutinib用途

Atuzabrutinib是一种有效的BTK(布鲁顿酪氨酸激酶)抑制剂(专利WO2016100914A1)[1]。

Atuzabrutinib名称

• 英文名: Atuzabrutinib

Atuzabrutinib生物活性

• 描述: Atuzabrutinib是一种有效的BTK(布鲁顿酪氨酸激酶)抑制剂(专利WO2016100914A1)[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
• 参考文献:

  [1]. Steven GOURLAY, et al. Treatment of pemphigus. WO2016100914A1.

Atuzabrutinib物理化学性质

• 分子式: C₃₀H₃₀FN₇O₂
• 分子量: 539.60
• InChIKey: KZMQPYCXSAGLTB-ZWUNQBBJSA-N
• SMILES: CC(C)(C)C=C(C#N)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1

Atuzabrutinib靶点实验

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实验名称：Toxicity in female Beagle dog assessed as NOAEL 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104966

实验名称：Mutagenicity in Salmonella typhimurium by Ames test 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104967

实验名称：Effect on canine pemphigus foliaceous dog model assessed as reduction in lesion at 8 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104968

实验名称：Toxicity in male Beagle dog assessed as drug tolerance up to 400 mg/kg/day qd for 12 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104962

实验名称：Toxicity in female Beagle dog assessed as reduction in activity up to 400 mg/kg/day q... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104963

实验名称：Toxicity in female Beagle dog assessed as weight loss up to 400 mg/kg/day qd for 12 w... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104964

实验名称：Toxicity in male Beagle dog assessed as NOAEL 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104965

实验名称：Enzymatic Activity Assay from US Patent US9090621: "Tyrosine kinase inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_7481_1

实验名称：Displacement of competitive tracer from BMX (unknown origin) assessed as target occup... 来源：ChEMBL 靶标：Cytoplasmic tyrosine-protein kinase BMX External Id：CHEMBL5104926

实验名称：Displacement of competitive tracer from ITK (unknown origin) assessed as target occup... 来源：ChEMBL 靶标：Tyrosine-protein kinase ITK/TSK External Id：CHEMBL5104927

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