9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl

• 常用名: 9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl
• 英文名: 9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl
• CAS号: 16006-64-7
• 分子量: 249.27
• 密度: 1.67g/cm3
• 沸点: 544.7ºC at 760mmHg
• 分子式: C₁₂H₁₅N₃O₃
• 熔点: N/A
• 闪点: 283.2ºC

用途

(2R,3S,5R)-2-(羟甲基)-5-(6-甲基-9H-嘌呤-9-基)四氢呋喃-3-醇(9-(2-脱氧-β-D-呋喃核糖基)-6-甲基嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 英文名: 6-methylpurine 2'-deoxyriboside

生物活性

• 描述: (2R,3S,5R)-2-(羟甲基)-5-(6-甲基-9H-嘌呤-9-基)四氢呋喃-3-醇(9-(2-脱氧-β-D-呋喃核糖基)-6-甲基嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

• 密度: 1.67g/cm3
• 沸点: 544.7ºC at 760mmHg
• 分子式: C₁₂H₁₅N₃O₃
• 分子量: 249.27
• 闪点: 283.2ºC
• 精确质量: 250.10700
• PSA: 93.29000
• InChIKey: SJXRKKYXNZWKDB-UHFFFAOYSA-N
• SMILES: Cc1ncnc2c1ncn2C1CC(O)C(CO)O1
• 蒸汽压: 1.07E-12mmHg at 25°C
• 折射率: 1.762

安全信息

• 海关编码: 2934999090

海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Activity of Escherichia coli PNP assessed per mg of protein at 100 uM by UV spectrome... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1930345

实验名称：Prodrug activation assessed as recombinant Escherichia coli PNP-mediated compound cle... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3755836

实验名称：Prodrug activation assessed as recombinant human MTAP-mediated compound cleavage at 1... 来源：ChEMBL 靶标：S-methyl-5'-thioadenosine phosphorylase External Id：CHEMBL3755835

实验名称：Prodrug activation assessed as recombinant human PNP-mediated compound cleavage at 10... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL3755834

实验名称：Terminal half life of compound in mouse plasma at 67 mg/kg, ip by reverse phase HPLC ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3755833

实验名称：Prodrug activation assessed as recombinant Escherichia coli SAH/MTA hydrolase-mediate... 来源：ChEMBL 靶标：5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase External Id：CHEMBL3755981

实验名称：Prodrug activation assessed as recombinant Sulfolobus solfataricus MTAP-mediated comp... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL3755839

实验名称：Prodrug activation assessed as recombinant Trichomonas vaginalis PNP-mediated compoun... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3755838

实验名称：Prodrug activation assessed as recombinant Escherichia coli PNP M64V mutant-mediated ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3755837

实验名称：Prodrug activation in human D54MG cells expressing Escherichia coli PNP xenografted i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3755985

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英文别名

• 6-methylpurine-2'-deoxyriboside
• 9-(2-deoxypentopyranosyl)-9h-purin-6-amine