9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-

更新时间:2024-01-03 20:05:24

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式
9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式
品牌特惠专场
常用名 9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- 英文名 9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-
CAS号 16006-64-7 分子量 249.27
密度 1.67g/cm3 沸点 544.7ºC at 760mmHg
分子式 C12H15N3O3 熔点 N/A
MSDS N/A 闪点 283.2ºC

 用途


(2R,3S,5R)-2-(羟甲基)-5-(6-甲基-9H-嘌呤-9-基)四氢呋喃-3-醇(9-(2-脱氧-β-D-呋喃核糖基)-6-甲基嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

 名称

英文名 6-methylpurine 2'-deoxyriboside
英文别名 更多

 生物活性

描述 (2R,3S,5R)-2-(羟甲基)-5-(6-甲基-9H-嘌呤-9-基)四氢呋喃-3-醇(9-(2-脱氧-β-D-呋喃核糖基)-6-甲基嘌呤)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
相关类别
参考文献

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 物理化学性质

密度 1.67g/cm3
沸点 544.7ºC at 760mmHg
分子式 C12H15N3O3
分子量 249.27
闪点 283.2ºC
精确质量 250.10700
PSA 93.29000
蒸汽压 1.07E-12mmHg at 25°C
折射率 1.762

 安全信息

海关编码 2934999090

 合成线路

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Cao, Chunyang; Jiang, Yu Lin; Krosky, Daniel J.; Stivers, James T. Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13034 - 13035

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Hassan; Abou-Elkair; Montgomery; Secrist III Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 7 p. 1123 - 1134

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Secrist III, John A. Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 745 - 757

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Boryski, Jerzy Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 1547 - 1556

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Boryski, Jerzy Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 1547 - 1556

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Boryski, Jerzy Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 1547 - 1556

~65%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-结构式

9H-Purine, 9-(2...

16006-64-7

文献:Votruba, Ivan; Holy, Antonin; Dvorakova, Hana; Guenter, Jaroslav; Hockova, Dana; et al. Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 10 p. 2303 - 2330

 海关

海关编码 2934999090
中文概述 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 英文别名

6-methylpurine-2'-deoxyriboside
9-(2-deoxypentopyranosyl)-9h-purin-6-amine