9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-

Modify Date: 2024-01-03 20:05:24

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure
9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- structure
Common Name 9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-
CAS Number 16006-64-7 Molecular Weight 249.27
Density 1.67g/cm3 Boiling Point 544.7ºC at 760mmHg
Molecular Formula C12H15N3O3 Melting Point N/A
MSDS N/A Flash Point 283.2ºC

 Use of 9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl-


(2R,3S,5R)-2-(hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3-ol (9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 6-methylpurine 2'-deoxyriboside
Synonym More Synonyms

  Biological Activity

Description (2R,3S,5R)-2-(hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3-ol (9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.67g/cm3
Boiling Point 544.7ºC at 760mmHg
Molecular Formula C12H15N3O3
Molecular Weight 249.27
Flash Point 283.2ºC
Exact Mass 250.10700
PSA 93.29000
Vapour Pressure 1.07E-12mmHg at 25°C
Index of Refraction 1.762

 Safety Information

HS Code 2934999090

 Synthetic Route

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9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Cao, Chunyang; Jiang, Yu Lin; Krosky, Daniel J.; Stivers, James T. Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13034 - 13035

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9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Hassan; Abou-Elkair; Montgomery; Secrist III Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 7 p. 1123 - 1134

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9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Secrist III, John A. Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 745 - 757

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9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Boryski, Jerzy Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 1547 - 1556

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9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Boryski, Jerzy Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 1547 - 1556

~%

9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Boryski, Jerzy Nucleosides and Nucleotides, 1998 , vol. 17, # 9-11 p. 1547 - 1556

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9H-Purine, 9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methyl- Structure

9H-Purine, 9-(2...

CAS#:16006-64-7

Literature: Votruba, Ivan; Holy, Antonin; Dvorakova, Hana; Guenter, Jaroslav; Hockova, Dana; et al. Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 10 p. 2303 - 2330

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

6-methylpurine-2'-deoxyriboside
9-(2-deoxypentopyranosyl)-9h-purin-6-amine