TH287

• 常用名: TH287
• 英文名: TH287
• CAS号: 1609960-30-6
• 分子量: 269.130
• 密度: 1.4±0.1 g/cm3
• 沸点: 512.2±60.0 °C at 760 mmHg
• 分子式: C₁₁H₁₀Cl₂N₄
• 熔点: N/A
• 闪点: 263.5±32.9 °C

TH287用途

TH287是MTH1 (NUDT1)高效选择性抑制剂,IC50值0.8nM,对MTH2, NUDT5, NUDT12, NUDT14等抑制力弱。

TH287名称

• 中文名: TH287
• 英文名: th287

TH287生物活性

• 描述: TH287是MTH1 (NUDT1)高效选择性抑制剂,IC50值0.8nM,对MTH2, NUDT5, NUDT12, NUDT14等抑制力弱。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 癌症
• 参考文献:

  [1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

TH287物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 512.2±60.0 °C at 760 mmHg
• 分子式: C₁₁H₁₀Cl₂N₄
• 分子量: 269.130
• 闪点: 263.5±32.9 °C
• 精确质量: 268.028259
• PSA: 37.81000
• LogP: 3.48
• InChIKey: URWCXPXBBITYLR-UHFFFAOYSA-N
• SMILES: CNc1cc(-c2cccc(Cl)c2Cl)nc(N)n1
• 外观性状: white solid
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.681
• 储存条件: 2-8℃

TH287靶点实验

查看更多实验

实验名称：Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinati... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_P

实验名称：Drug screen in ICB984 medulloblastoma cells to determine synergistic drug combination... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_ICB984_MB

实验名称：Drug screen in HDN33 neuroblastoma cells to determine synergistic drug combinations t... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HDN33

实验名称：Drug screen in HD-MB03 medulloblastoma cells to determine synergistic drug combinatio... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HD-MB03

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Drug screen in CRL2098 osteosarcoma cells to determine synergistic drug combinations ... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_CRL2098

实验名称：Inhibition of MTH1 in human U2OS cell lysates assessed as hydrolysis of 8-oxodGTP to ... 来源：ChEMBL 靶标：Oxidized purine nucleoside triphosphate hydrolase External Id：CHEMBL3783609

实验名称：Binding affinity to recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unk... 来源：ChEMBL 靶标：Oxidized purine nucleoside triphosphate hydrolase External Id：CHEMBL4339322

实验名称：Inhibition of MTH1 in human U2OS cells assessed as hydrolysis of 8-oxodGTP to 8-oxodG... 来源：ChEMBL 靶标：Oxidized purine nucleoside triphosphate hydrolase External Id：CHEMBL3783608

实验名称：Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubat... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL4345256

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TH287英文别名

• 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
• 6-(2,3-Dichlorophenyl)-N-methyl-2,4-pyrimidinediamine