AL-611

• 常用名: AL-611
• 英文名: AL-611
• CAS号: 1613591-70-0
• 分子量: 614.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₃F₂N₆O₈P
• 熔点: N/A
• 闪点: N/A

AL-611用途

AL-611是一种HCV NS5B聚合酶抑制剂(EC50=5 nM)。

AL-611名称

• 英文名: AL-611

AL-611生物活性

• 描述: AL-611是一种HCV NS5B聚合酶抑制剂(EC50=5 nM)。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> HCV蛋白酶
• 参考文献:

  [1]. Wang G, et al. Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C. J Med Chem. 2020 Sep 24;63(18):10380-10395.

AL-611物理化学性质

• 分子式: C₂₅H₃₃F₂N₆O₈P
• 分子量: 614.54
• InChIKey: ZPUNZSJZZGWNSN-UNWTUYFGSA-N
• SMILES: CCOc1nc(N)nc2c1ncn2C1OC(F)(COP(=O)(NC(C)C(=O)OC(C)C)Oc2ccccc2)C(O)C1(C)F

AL-611靶点实验

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实验名称：Selectivity index, ratio of CC50 for human HuH7 cells infected with HCV con1 subgenom... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627030

实验名称：Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon asse... 来源：ChEMBL 靶标：Huh-7 External Id：CHEMBL4627029

实验名称：Prodrug activation in human hepatocytes assessed as [[(2S,3S,4R,5R)-5-(2-amino-6-oxo-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627038

实验名称：Prodrug activation in human hepatocytes assessed as nucleoside monophosphate metaboli... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627037

实验名称：Prodrug activation in human hepatocytes assessed as [[(2S,3S,4R,5R)-5-(2-amino-6-oxo-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627040

实验名称：Prodrug activation in human hepatocytes assessed as time at which [[(2S,3S,4R,5R)-5-(... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627039

实验名称：Prodrug activation in human hepatocytes assessed as half life of [[(2S,3S,4R,5R)-5-(2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627041

实验名称：Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells ... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL4627028

实验名称：Prodrug activation in human hepatocytes assessed as [[(2S,3S,4R,5R)-5-(2-amino-6-oxo-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4627043

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