LU-005i

• 常用名: LU-005i
• 英文名: LU-005i
• CAS号: 1620107-33-6
• 分子量: 586.72
• 密度: 1.189±0.06 g/cm3(Predicted)
• 沸点: 860.2±65.0 °C(Predicted)
• 分子式: C₃₁H₄₆N₄O₇
• 熔点: N/A
• 闪点: N/A

LU-005i用途

LU-005i 是免疫蛋白酶体 β5i 亚基的强效抑制剂 (IC50 = 6.6 nM),选择性高于 β5c 亚基 (IC50 = 287 nM)。

LU-005i名称

• 英文名: L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-N-[(1S)-1-(cyclohexylmethyl)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl]-O-methyl

LU-005i生物活性

• 描述: LU-005i 是免疫蛋白酶体 β5i 亚基的强效抑制剂 (IC50 = 6.6 nM),选择性高于 β5c 亚基 (IC50 = 287 nM)。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点实验:

  β5i subunit of immunoproteasomes (IC50 = 6.6 nM), β5c subunit of immunoproteasomes (IC50 = 287 nM)[1]

• 参考文献:

  [1]. Rezvan Moallemian, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.Biochem Pharmacol. 2020 Jul:177:113964.

LU-005i物理化学性质

• 密度: 1.189±0.06 g/cm3(Predicted)
• 沸点: 860.2±65.0 °C(Predicted)
• 分子式: C₃₁H₄₆N₄O₇
• 分子量: 586.72

LU-005i靶点实验

查看更多实验

实验名称：Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fl... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL3371271

实验名称：Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371272

实验名称：Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxom... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371275

实验名称：Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin... 来源：ChEMBL 靶标：Proteasome subunit beta type-10 External Id：CHEMBL3371276

实验名称：Ratio of IC50 for 20s proteasome subunit beta-5c to IC50 for proteasome subunit beta-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371273

实验名称：Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin... 来源：ChEMBL 靶标：Proteasome subunit beta type-9 External Id：CHEMBL3371274

实验名称：Ratio of IC50 for proteasome subunit beta-2i to IC50 for proteasome subunit beta-5i i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371279

实验名称：Ratio of IC50 for 20s proteasome subunit beta-2c to IC50 for proteasome subunit beta-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371280

实验名称：Inhibition of 20s proteasome subunit beta-2c in human Raji cells using BODIPY- epoxom... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371277

实验名称：Ratio of IC50 for proteasome subunit beta-1i to IC50 for proteasome subunit beta-5i i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371278

共20条，当前第1页，共2页

1

2