LU-005i

Modify Date: 2025-08-26 22:32:22

LU-005i Structure
LU-005i structure
Common Name LU-005i
CAS Number 1620107-33-6 Molecular Weight 586.72
Density 1.189±0.06 g/cm3(Predicted) Boiling Point 860.2±65.0 °C(Predicted)
Molecular Formula C31H46N4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LU-005i


LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].

 Names

Name L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-N-[(1S)-1-(cyclohexylmethyl)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl]-O-methyl-

 LU-005i Biological Activity

Description LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].
Related Catalog
Target

β5i subunit of immunoproteasomes (IC50 = 6.6 nM), β5c subunit of immunoproteasomes (IC50 = 287 nM)[1]

References

[1]. Rezvan Moallemian, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.Biochem Pharmacol. 2020 Jul:177:113964.  

 Chemical & Physical Properties

Density 1.189±0.06 g/cm3(Predicted)
Boiling Point 860.2±65.0 °C(Predicted)
Molecular Formula C31H46N4O7
Molecular Weight 586.72
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