Pf-06371900

• 常用名: Pf-06371900
• 英文名: Pf-06371900
• CAS号: 1622291-81-9
• 分子量: 368.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₆N₆O₂S
• 熔点: N/A
• 闪点: N/A

Pf-06371900用途

PF-06371900是一种有效且高度选择性的富含亮氨酸重复激酶2(LRRK2)抑制剂[1]。

Pf-06371900名称

• 英文名: PF-06371900

Pf-06371900生物活性

• 描述: PF-06371900是一种有效且高度选择性的富含亮氨酸重复激酶2(LRRK2)抑制剂[1]。
• 相关类别:
  信号通路 >> 自噬 >> LRRK2
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Henderson JL, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.

Pf-06371900物理化学性质

• 分子式: C₁₇H₁₆N₆O₂S
• 分子量: 368.41

Pf-06371900靶点实验

查看更多实验

实验名称：Permeability assessed as doxycycline-induced mouse BCRP-mediated permeability from ba... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL3368818

实验名称：Efflux ratio of permeability from basolateral to apical side to apical to basolateral... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL3368819

实验名称：Permeability assessed as doxycycline-induced mouse BCRP-mediated permeability from ap... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL3368817

实验名称：Efflux ratio of permeability from basolateral to apical side to apical to basolateral... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL3368822

实验名称：Permeability assessed as mouse BCRP-mediated permeability from apical to basolateral ... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL3368820

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Permeability assessed as mouse BCRP-mediated permeability from basolateral to apical ... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL3368821

实验名称：AUC (0 to 24 hrs) in mouse at 30 mg/kg/day, po for 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3367456

实验名称：AUC (0 to 24 hrs) in mouse at 300 mg/kg/day, po for 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3367457

实验名称：Toxicity in mouse assessed as change in liver histology at 30 to 300 mg/kg/day, po fo... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3367460

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