VR23

• 常用名: VR23
• 英文名: VR23
• CAS号: 1624602-30-7
• 分子量: 477.878
• 密度: 1.6±0.1 g/cm3
• 沸点: 699.3±65.0 °C at 760 mmHg
• 分子式: C₁₉H₁₆ClN₅O₆S
• 熔点: N/A
• 闪点: 376.7±34.3 °C

VR23用途

VR23有效抑制胰蛋白酶样蛋白酶 (IC50=1nM), 胰凝乳蛋白酶样蛋白酶 (IC50 =50-100 nM), 和caspase样蛋白酶 (IC50 =3μM)。

VR23名称

• 中文名: 7-氯-4-[4-[(2,4-二硝基苯基)磺酰基]-1-哌嗪基]喹啉
• 英文名: 7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline

VR23生物活性

• 描述: VR23有效抑制胰蛋白酶样蛋白酶 (IC50=1nM), 胰凝乳蛋白酶样蛋白酶 (IC50 =50-100 nM), 和caspase样蛋白酶 (IC50 =3μM)。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Pundir S, et al. VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification. Cancer Res. 2015 Oct 1;75(19):4164-4175.

  [2]. Lee Hoyun, et al. Preparation of quinoline sulfonyl derivatives for the treatment of cancer. From PCT Int. Appl. (2014), WO 2014134705 A1 20140912.

VR23物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 699.3±65.0 °C at 760 mmHg
• 分子式: C₁₉H₁₆ClN₅O₆S
• 分子量: 477.878
• 闪点: 376.7±34.3 °C
• 精确质量: 477.050995
• LogP: 3.49
• InChIKey: PDQVZPPIHADUOO-UHFFFAOYSA-N
• SMILES: O=[N+]([O-])c1ccc(S(=O)(=O)N2CCN(c3ccnc4cc(Cl)ccc34)CC2)c([N+](=O)[O-])c1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.697
• 储存条件: -20℃

VR23靶点实验

查看更多实验

实验名称：Confirmatory qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC 靶标：N/A External Id：APP-Toga-CHIKV-nsP2-f2-f9

实验名称：NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C... 来源：NCGC 靶标：N/A External Id：adst_HEK293_Anti-infectives-02

实验名称：Selectivity profile for inhibitors of NSP2Pro chikungunya virus (CHIKV): Papain Count... 来源：NCGC External Id：APP-Toga-CHIKV-nsP2-f3_f16

实验名称：NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay 来源：NCGC 靶标：N/A External Id：adst_Celegans_Anti-infectives-o1

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Selectivity profile for inhibitors of NSP2Pro chikungunya virus (CHIKV): NS34A-HCV Co... 来源：NCGC External Id：APP-Toga-CHIKV-nsP2-f

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Selectivity profile for inhibitors of NSP2Pro chikungunya virus (CHIKV): Full length ... 来源：NCGC External Id：APP-Toga-CHIKV-nsP2-full-length

实验名称：Secondary cell base assay for inhibitors of NSP2Pro Chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsP2-f18-cell-based

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

共12条，当前第1页，共2页

1

2

VR23英文别名

• 7-Chloro-4-{4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl}quinoline
• VR23