SGK1-IN-4

• 常用名: SGK1-IN-4
• 英文名: SGK1-IN-4
• CAS号: 1628048-93-0
• 分子量: 517.96
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₁ClFN₅O₄S
• 熔点: N/A
• 闪点: N/A

SGK1-IN-4用途

SGK1-IN-4(化合物17a)是一种高选择性、口服活性SGK1抑制剂。SGK1-IN-4可用于骨关节炎研究[1]。

SGK1-IN-4名称

• 英文名: SGK1-IN-4

SGK1-IN-4生物活性

• 描述: SGK1-IN-4(化合物17a)是一种高选择性、口服活性SGK1抑制剂。SGK1-IN-4可用于骨关节炎研究[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> SGK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Nis Halland, et al. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem. 2022 Jan 27;65(2):1567-1584.

SGK1-IN-4物理化学性质

• 分子式: C₂₃H₂₁ClFN₅O₄S
• 分子量: 517.96
• InChIKey: IKBMUGXVSJZWGW-UHFFFAOYSA-N
• SMILES: O=S(=O)(Nc1ccc(-c2nc(OC3CCC(O)CC3)c3cn[nH]c3n2)cc1)c1cc(Cl)ccc1F

SGK1-IN-4靶点实验

查看更多实验

实验名称：Inhibition of SGK1 (unknown origin) assessed as substrate phosphorylation 来源：ChEMBL 靶标：Serine/threonine-protein kinase Sgk1 External Id：CHEMBL3379050

实验名称：Mutagenicity in Salmonella typhimurium T98 in presence of S9 fraction by ames test 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL5043770

实验名称：Mutagenicity in Salmonella typhimurium T98 by ames test 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL5043771

实验名称：Inhibition of CYP3A4 in human liver microsomes by measuring maximum efficacy 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5043762

实验名称：Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5043761

实验名称：Intrinsic clearance in human hepatocytes assessed per 10^-6 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043760

实验名称：Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound degra... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043759

实验名称：Inhibition of human ERG at 10 uM 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL5043764

实验名称：Inhibition of human ERG at 1 uM relative to control 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL5043763

实验名称：Enzymatic Activity Assay from US Patent US9718825: "N-(4-(azaindazol-6-yl)-phenyl)-su... 来源：BindingDB 靶标：N/A External Id：BindingDB_432_1

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