MI-136

• 常用名: MI-136
• 英文名: MI-136
• CAS号: 1628316-74-4
• 分子量: 470.51300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₁F₃N₆S
• 熔点: N/A
• 闪点: N/A

MI-136用途

MI-136抑制DHT诱导的雄激素受体(AR)靶基因表达。

MI-136名称

• 中文名: 5-[(4-{[6-(2,2,2-三氟乙基)噻吩并[2,3-d]嘧啶-4-基]氨基}哌啶-1-基)甲基]-1H-吲哚-2-甲腈
• 英文名: 5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile

MI-136生物活性

• 描述: MI-136抑制DHT诱导的雄激素受体(AR)靶基因表达。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Malik R, et al. Targeting the MLL complex in castration-resistant prostate cancer. Nat Med. 2015 Apr;21(4):344-52.

MI-136物理化学性质

• 分子式: C₂₃H₂₁F₃N₆S
• 分子量: 470.51300
• 精确质量: 470.15000
• PSA: 108.87000
• LogP: 5.23648
• 外观性状: 粉末
• 储存条件: -20℃

MI-136靶点实验

查看更多实验

实验名称：Oral bioavailability in C57BL/6 mouse at 30 mg/kg after 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3782842

实验名称：Volume of distribution at steady state in C57BL/6 mouse at 15 mg/kg, iv after 24 hrs ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3782840

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Growth inhibition of MLL-AF9 transformed mouse bone marrow cells after 7 days by MTT ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3782823

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of menin-MLL interaction (unknown origin) after 1 hr by fluorescence polar... 来源：ChEMBL 靶标：Menin External Id：CHEMBL3782822

实验名称：Tmax in C57BL/6 mouse plasma at 30 mg/kg, po after 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3782827

实验名称：Half life in CD-1 mouse liver microsomes at 1 uM after 3 to 60 mins by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3782826

实验名称：Substrate activity at aldehyde oxidase in human liver cytosol at 10 uM measured after... 来源：ChEMBL 靶标：Aldehyde oxidase External Id：CHEMBL4615005

实验名称：Selectivity index, ratio of GI50 for Hoxa9/Meis1 transformed mouse bone marrow cells ... 来源：ChEMBL 靶标：Bone marrow cell External Id：CHEMBL3782825

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MI-136英文别名

• MI-136
• 5-[[4-[[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrile
• 5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile