Arylquin-1

• 常用名: Arylquin-1
• 英文名: Arylquin-1
• CAS号: 1630743-73-5
• 分子量: 281.327
• 密度: 1.2±0.1 g/cm3
• 沸点: 441.4±40.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆FN₃
• 熔点: N/A
• 闪点: 220.7±27.3 °C

Arylquin-1用途

Arylquin 1是一种前列腺凋亡反应-4(Par-4)促分泌剂,以波形蛋白为靶点诱导Par-4分泌。芳基喹1通过诱导溶酶体膜通透性(LMP)诱导癌细胞非凋亡性细胞死亡【1】。

Arylquin-1名称

• 英文名: Arylquin 1

Arylquin-1生物活性

• 描述: Arylquin 1是一种前列腺凋亡反应-4(Par-4)促分泌剂,以波形蛋白为靶点诱导Par-4分泌。芳基喹1通过诱导溶酶体膜通透性(LMP)诱导癌细胞非凋亡性细胞死亡【1】。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症

Arylquin-1物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 441.4±40.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆FN₃
• 分子量: 281.327
• 闪点: 220.7±27.3 °C
• 精确质量: 281.132813
• LogP: 4.49
• InChIKey: RHAQINSYYSNKKI-UHFFFAOYSA-N
• SMILES: CN(C)c1ccc2cc(-c3ccccc3F)c(N)nc2c1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.677

Arylquin-1安全信息

• 危险品运输编码: NONH for all modes of transport

Arylquin-1靶点实验

查看更多实验

实验名称：Metabolic stability in mouse liver microsomes assessed as clearance measured upto 4 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5228455

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Metabolic stability in mouse liver microsomes assessed as half life measured upto 4 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5228454

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

实验名称：Selectivity index, ratio of EC50 for mouse J774A.1 cells to EC50 for Leishmania mexic... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5228448

实验名称：Cytotoxicity against mouse J774A.1 cells measured after 1 hr in dark by SYBR Green I ... 来源：ChEMBL 靶标：J774.A1 External Id：CHEMBL5228447

实验名称：Antileishmanial activity against Leishmania mexicana promastigote infected in mouse J... 来源：ChEMBL 靶标：Leishmania mexicana External Id：CHEMBL5228446

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Arylquin-1英文别名

• 3-(2-Fluorophenyl)-N7,N7-dimethylquinoline-2,7-diamine)
• Arylquin 1
• MFCD28580129
• 3-(2-Fluorophenyl)-N7,N7-dimethyl-2,7-quinolinediamine