URAT1 inhibitor 7

• 常用名: URAT1 inhibitor 7
• 英文名: URAT1 inhibitor 7
• CAS号: 1632002-28-8
• 分子量: 428.82
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₀ClFN₄O₃S
• 熔点: N/A
• 闪点: N/A

URAT1 inhibitor 7用途

URAT1抑制剂7(化合物10f)是具有12nM的IC50的强效URAT1抑制物。URAT1抑制剂7表现出微粒体稳定性(HLM<13µL/min/mg)。URAT1抑制剂7也抑制CYP2C9,IC50为4.2μM。URAT1抑制剂7可用于痛风研究[1]。

URAT1 inhibitor 7名称

• 英文名: URAT1 inhibitor 7

URAT1 inhibitor 7生物活性

• 描述: URAT1抑制剂7(化合物10f)是具有12nM的IC50的强效URAT1抑制物。URAT1抑制剂7表现出微粒体稳定性(HLM<13µL/min/mg)。URAT1抑制剂7也抑制CYP2C9,IC50为4.2μM。URAT1抑制剂7可用于痛风研究[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> URAT1
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Storer R I, et al. The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm, 2016:10.1039.C6MD00190D.

URAT1 inhibitor 7物理化学性质

• 分子式: C₁₉H₁₀ClFN₄O₃S
• 分子量: 428.82

URAT1 inhibitor 7靶点实验

查看更多实验

实验名称：Mutagenicity in Salmonella typhi by Ames test in absence of S4 fraction 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3853464

实验名称：Inhibition Assay from US Patent US9067922: "Chemical compounds" 来源：BindingDB 靶标：N/A External Id：BindingDB_7004_1

实验名称：Mutagenicity in Salmonella typhi by Ames test in presence of S4 fraction 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3853463

实验名称：Intrinsic clearance in human hepatocytes assessed per 10'6 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3853469

实验名称：Intrinsic clearance in rat hepatocytes assessed per 10'6 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3853470

实验名称：Intrinsic clearance in dog hepatocytes assessed per 10'6 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3853471

实验名称：Fraction unbound in rat plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL3853448

实验名称：Fraction unbound in dog plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL3853449

实验名称：Drug uptake assessed as human OATP1B1-mediated drug accumulation by cell-based assay ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL3853450

实验名称：Drug uptake assessed as human OATP1B3-mediated drug accumulation by cell-based assay ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL3853451

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