RSK2-IN-2

• 常用名: RSK2-IN-2
• 英文名: RSK2-IN-2
• CAS号: 1637749-78-0
• 分子量: 289.29
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₁N₅O
• 熔点: N/A
• 闪点: N/A

RSK2-IN-2用途

RSK2-IN-2(化合物25)是RPS6KA3(RSK2)激酶的可逆共价抑制剂。RSK2-IN-2也被描述为抑制MSK1、MSK2和RSK3[1]。

RSK2-IN-2名称

• 英文名: RSK2-IN-2

RSK2-IN-2生物活性

• 描述: RSK2-IN-2(化合物25)是RPS6KA3(RSK2)激酶的可逆共价抑制剂。RSK2-IN-2也被描述为抑制MSK1、MSK2和RSK3[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> 核糖体S6激酶(RSK)
• 靶点实验:

  RSK2

  RSK3

  MSK1

  MSK2

• 体外研究: RSK2-IN-2(化合物25)显示出较强的活性,ERK2-MSK1级联pIC50为9.6[1]。
• 参考文献:

  [1]. Hall A, et al. Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. ACS Med Chem Lett. 2022 Jun 25;13(7):1099-1108.

RSK2-IN-2物理化学性质

• 分子式: C₁₆H₁₁N₅O
• 分子量: 289.29

RSK2-IN-2靶点实验

查看更多实验

实验名称：Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 r... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149637

实验名称：Covalent binding affinity to N-terminal His-Smt-tagged MSK1 C-terminal kinase domain ... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149662

实验名称：Covalent binding affinity to N-terminal His-Smt-tagged MSK1 C-terminal kinase domain ... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149660

实验名称：Covalent binding affinity to N-terminal His-Smt-tagged MSK1 C-terminal kinase domain ... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149661

实验名称：Binding affinity to N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 7... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149654

实验名称：Binding affinity to N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 7... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149655

实验名称：Covalent binding affinity to N-terminal His-Smt-tagged MSK1 C-terminal kinase domain ... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5149672

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