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ONC-201 Dihydrochloride

更新时间:2025-08-26 23:13:54

ONC-201 Dihydrochloride结构式
ONC-201 Dihydrochloride结构式
品牌特惠专场
常用名 ONC-201 Dihydrochloride 英文名 ONC-201 Dihydrochloride
CAS号 1638178-82-1 分子量 459.411
密度 N/A 沸点 N/A
分子式 C24H28Cl2N4O 熔点 N/A
MSDS N/A 闪点 N/A

 ONC-201 Dihydrochloride用途


ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.

 ONC-201 Dihydrochloride名称

英文名 ONC-201 DIHYDROCHLORIDE
英文别名 更多

 ONC-201 Dihydrochloride物理化学性质

分子式 C24H28Cl2N4O
分子量 459.411
精确质量 458.164032

 ONC-201 Dihydrochloride英文别名

Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-, hydrochloride (1:2)
7-Benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one dihydrochloride
ONC-201 DIHYDROCHLORIDE
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ONC-201 Dihydrochloride生产厂家

ONC-201 Dihydrochloride价格

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