MmpL3-IN-3

• 常用名: MmpL3-IN-3
• 英文名: MmpL3-IN-3
• CAS号: 1639438-67-7
• 分子量: 437.09
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₃ClN₂Si
• 熔点: N/A
• 闪点: N/A

MmpL3-IN-3用途

MmpL3-IN-3(化合物12)是MmpL3抑制剂。MmpL3-IN-3对H37Rv的MIC为0.1μ。MmpL3-IN-3在小鼠肝微粒体中显示出良好的稳定性。MmpL3-IN-3可用于抗结核研究[1]。

MmpL3-IN-3名称

• 英文名: MmpL3-IN-3

MmpL3-IN-3生物活性

• 描述: MmpL3-IN-3(化合物12)是MmpL3抑制剂。MmpL3-IN-3对H37Rv的MIC为0.1μ。MmpL3-IN-3在小鼠肝微粒体中显示出良好的稳定性。MmpL3-IN-3可用于抗结核研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Vasudevan N, et al. Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors: An effective strategy towards development of potent anti-tubercular agents. Eur J Med Chem. 2023 Jul 16;259:115633.

MmpL3-IN-3物理化学性质

• 分子式: C₂₆H₃₃ClN₂Si
• 分子量: 437.09
• InChIKey: TUZINMIDJHOXOL-UHFFFAOYSA-N
• SMILES: CCc1ccc(-n2c(-c3ccc(Cl)cc3)cc(CN3CC[Si](C)(C)CC3)c2C)cc1

MmpL3-IN-3靶点实验

查看更多实验

实验名称：Metabolic stability in human plasma at 50 uM measured after 60 mins by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634656

实验名称：Metabolic stability in mouse liver microsomes at 50 uM measured after 30 mins by LC-M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634657

实验名称：Metabolic stability in human liver microsomes at 50 uM measured after 30 mins by LC-M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634658

实验名称：Protein binding in human plasma at 150 uM by equilibrium dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634659

实验名称：Cytotoxicity against HEK293 cells assessed as reduction in cell viability at >45 uM m... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL5634660

实验名称：Selectivity index, ratio of IC50 for cytotoxicity against HEK293 cells to MIC for ant... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634661

实验名称：Selectivity index, ratio of IC50 for cytotoxicity against mouse primary astrocytes ce... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5634662

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as inhibiti... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5634650

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