利莫纳班

• 常用名: 利莫纳班
• 英文名: Rimonabant
• CAS号: 168273-06-1
• 分子量: 463.787
• 密度: 1.4±0.1 g/cm3
• 沸点: 627.6ºC at 760 mmHg
• 分子式: C₂₂H₂₁Cl₃N₄O
• 熔点: 230-240ºC
• 闪点: 333.3ºC

利莫纳班用途

Rimonabant(SR141716)是中心CB1受体反向激动剂,Ki为1.8 nM。

利莫纳班名称

• 中文名: 利莫那班
• 英文名: Rimonabant
• 中文别名: 5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺 | 利莫纳班

利莫纳班生物活性

• 描述: Rimonabant(SR141716)是中心CB1受体反向激动剂,Ki为1.8 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Heppenstall C, Bunce S, Smith JC. Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant. Nutr J. 2012 Jul 23;11(1):50.

  [2]. Seely KA, Brents LK, Franks LN, Rajasekaran M, Zimmerman SM, Fantegrossi WE, Prather PL. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):9

  [3]. Mandhane S, Nayak P, Soni D, Jain S, Ashton JC, Rajamannar T. Induction of glucose intolerance by acute administration of rimonabant. Pharmacology. 2012;89(5-6):339-47.

  [4]. Leite, C.E., Mocelin, C.A., Petersen, G.O., et al. Rimonabant: An antagonist drug of the endocannabinoid system for the treatment of obesity. Pharmacol Rep 61 217-224 (2009).

  [5]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.

利莫纳班物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 627.6ºC at 760 mmHg
• 熔点: 230-240ºC
• 分子式: C₂₂H₂₁Cl₃N₄O
• 分子量: 463.787
• 闪点: 333.3ºC
• 精确质量: 462.078094
• PSA: 50.16000
• LogP: 6.01
• InChIKey: JZCPYUJPEARBJL-UHFFFAOYSA-N
• SMILES: Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1
• 外观性状: 白色或近乎于白色结晶粉末
• 折射率: 1.668
• 储存条件: 2~8°C

利莫纳班MSDS

利莫纳班MSDS英文版

利莫纳班安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

利莫纳班海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

利莫纳班靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Receptor occupancy at CB1 receptor in rat frontal cortex at 3 to 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3364145

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Antidiabetic activity in streptozotocin/nicotinamide-induced Wistar rat model of diab... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3792115

实验名称：Antidiabetic activity in streptozotocin/nicotinamide-induced Wistar rat model of diab... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3792114

实验名称：Antidiabetic activity in streptozotocin/nicotinamide-induced Wistar rat model of diab... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3792113

实验名称：Antidiabetic activity in streptozotocin/nicotinamide-induced Wistar rat model of diab... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3792112

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with ... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL663455

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

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利莫纳班英文别名

• 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
• rimonabant
• 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide
• Acomplia
• Unii-rml78en3xe
• SR-141716A
• SR141716A
• Zimulti
• MFCD04034714
• A 281