Ro 25-6981

• 常用名: Ro 25-6981
• 英文名: Ro 25-6981
• CAS号: 169274-78-6
• 分子量: 339.47
• 密度: N/A
• 沸点: 703.7ºC at 760mmHg
• 分子式: C₂₂H₂₉NO₂
• 熔点: N/A
• 闪点: 379.4ºC

Ro 25-6981用途

Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂,对于重组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 μM。

Ro 25-6981名称

• 中文名: Ro 25-6981
• 英文名: 4-[(1S,2R)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol,but-2-enedioic acid

Ro 25-6981生物活性

• 描述: Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂,对于重组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.

  [2]. Lynch DR, et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol. 2001 Mar 30;416(3):185-95.

  [3]. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.

Ro 25-6981物理化学性质

• 沸点: 703.7ºC at 760mmHg
• 分子式: C₂₂H₂₉NO₂
• 分子量: 339.47
• 闪点: 379.4ºC
• PSA: 118.30000
• LogP: 3.66610
• InChIKey: WVZSEUPGUDIELE-HTAPYJJXSA-N
• SMILES: CC(CN1CCC(Cc2ccccc2)CC1)C(O)c1ccc(O)cc1
• 蒸汽压: 2.52E-11mmHg at 25°C
• 折射率: 1.587
• 储存条件: 2-8℃

Ro 25-6981英文别名

• Ro 25-6981