GSK8573

• 常用名: GSK8573
• 英文名: GSK-8573
• CAS号: 1693766-04-9
• 分子量: 323.386
• 密度: 1.1±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₁NO₃
• 熔点: N/A
• 闪点: N/A

GSK8573用途

GSK8573 是 GSK2801 的非活性对照化合物。GSK8573 与 BRD9 具有结合活性,Kd 值为 1.04 μM,并且对 BAZ2A/B 和其他溴结构域家族无抑制活性。

GSK8573名称

• 英文名: 1-[1-(3-Methoxyphenyl)-7-propoxy-3-indolizinyl]ethanone

GSK8573生物活性

• 描述: GSK8573 是 GSK2801 的非活性对照化合物。GSK8573 与 BRD9 具有结合活性,Kd 值为 1.04 μM,并且对 BAZ2A/B 和其他溴结构域家族无抑制活性。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  BRD9:1.04 μM (Kd)

• 参考文献:

  [1]. Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59(4):1410-24.

GSK8573物理化学性质

• 密度: 1.1±0.1 g/cm3
• 分子式: C₂₀H₂₁NO₃
• 分子量: 323.386
• 精确质量: 323.152130
• LogP: 4.44
• InChIKey: QQBGNWWJANJWNY-UHFFFAOYSA-N
• SMILES: CCCOc1ccn2c(C(C)=O)cc(-c3cccc(OC)c3)c2c1
• 外观性状: 浅黄色固体
• 折射率: 1.569
• 储存条件: -20℃

GSK8573靶点实验

查看更多实验

实验名称：Binding affinity to biotinylated BRD9 (unknown origin) expressed in Escherichia coli ... 来源：ChEMBL 靶标：Bromodomain-containing protein 9 External Id：CHEMBL5713042

实验名称：Thermal Shift Assay. Domain: start/stop: G861-E979 来源：ChEMBL 靶标：Transcription intermediary factor 1-alpha External Id：CHEMBL5068688

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Binding affinity to biotinylated C-terminal Avi/His-TEV-tagged BAZ2A (unknown origin)... 来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2A External Id：CHEMBL3773108

实验名称：Binding affinity to biotinylated ATAD2 (unknown origin) expressed in Escherichia coli... 来源：ChEMBL 靶标：ATPase family AAA domain-containing protein 2 External Id：CHEMBL3773107

实验名称：Binding affinity to biotinylated ASH1L bromodomain (unknown origin) expressed in Esch... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase ASH1L External Id：CHEMBL3773106

实验名称：Binding affinity to biotinylated BRD2 bromodomain-2 (unknown origin) expressed in Esc... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL3773112

实验名称：Thermal Shift Assay. Domain: start/stop: N44-E168 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5061256

实验名称：Binding affinity to biotinylated BRD2 bromodomain-1 (unknown origin) expressed in Esc... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL3773111

实验名称：Binding affinity to biotinylated BRD1 (unknown origin) expressed in Escherichia coli ... 来源：ChEMBL 靶标：Bromodomain-containing protein 1 External Id：CHEMBL3773110

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GSK8573英文别名

• 1-[1-(3-Methoxyphenyl)-7-propoxy-3-indolizinyl]ethanone
• GSK-8573