(RS)-APICA

• 常用名: (RS)-APICA
• 英文名: (RS)-APICA
• CAS号: 170847-18-4
• 分子量: 257.18
• 密度: 1.6±0.1 g/cm3
• 沸点: 559.9±60.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂NO₅P
• 熔点: N/A
• 闪点: 292.4±32.9 °C

(RS)-APICA用途

APICA是一种有效的CB1和CB2受体激动剂,对CB1和CB2受体的EC50值分别为118 nM和37 nM。APICA在体内具有拟大麻活性[1]。

(RS)-APICA名称

• 英文名: 1-Amino-5-phosphono-1-indanecarboxylic acid

(RS)-APICA生物活性

• 描述: APICA是一种有效的CB1和CB2受体激动剂,对CB1和CB2受体的EC50值分别为118 nM和37 nM。APICA在体内具有拟大麻活性[1]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 靶点实验:

  hCB2-R:37 nM (EC50)

  hCB1-R:118 nM (EC50)

• 参考文献:

  [1]. Longworth M, et al. Synthesis and Pharmacological Profiling of the Metabolites of Synthetic Cannabinoid Drugs APICA, STS-135, ADB-PINACA, and 5F-ADB-PINACA. ACS Chem Neurosci. 2017 Aug 16;8(8):1673-1680.

(RS)-APICA物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 559.9±60.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂NO₅P
• 分子量: 257.18
• 闪点: 292.4±32.9 °C
• 精确质量: 257.045319
• LogP: -0.89
• InChIKey: ZNQZXIHSJUDIKL-UHFFFAOYSA-N
• SMILES: NC1(C(=O)O)CCc2cc(P(=O)(O)O)ccc21
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.671

(RS)-APICA靶点实验

查看更多实验

实验名称：Antagonist potency against cloned Metabotropic glutamate receptor 2 来源：ChEMBL 靶标：Metabotropic glutamate receptor 2 External Id：CHEMBL718218

实验名称：Antagonistic activity against Metabotropic glutamate receptor 5 was determined at 1 m... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL709907

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3... 来源：NCGC External Id：epac1-inhibitor-v

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E... 来源：NCGC External Id：epac2-activator-v2

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4... 来源：NCGC External Id：epac2-inhibitor-v2

实验名称：Agonist potency against cloned human metabotropic glutamate receptor 1 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL719076

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

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(RS)-APICA英文别名

• 1-Amino-5-phosphono-1-indanecarboxylic acid
• 1-Amino-5-phosphonoindane-1-carboxylic acid